Photochemical and electrochemical applications of proton-coupled electron transfer in organic synthesis

PRD Murray, JH Cox, ND Chiappini, CB Roos… - Chemical …, 2021 - ACS Publications
We present here a review of the photochemical and electrochemical applications of multi-
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …

US FDA approved drugs from 2015–June 2020: a perspective

P Bhutani, G Joshi, N Raja, N Bachhav… - Journal of Medicinal …, 2021 - ACS Publications
In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …

First-row d-block element-catalyzed carbon–boron bond formation and related processes

SK Bose, L Mao, L Kuehn, U Radius… - Chemical …, 2021 - ACS Publications
Organoboron reagents represent a unique class of compounds because of their utility in
modern synthetic organic chemistry, often affording unprecedented reactivity. The …

Diboron (4) compounds: from structural curiosity to synthetic workhorse

EC Neeve, SJ Geier, IAI Mkhalid, SA Westcott… - Chemical …, 2016 - ACS Publications
Although known for over 90 years, only in the past two decades has the chemistry of diboron
(4) compounds been extensively explored. Many interesting structural features and reaction …

Boronic acids as building blocks for the construction of therapeutically useful bioconjugates

JPM António, R Russo, CP Carvalho… - Chemical Society …, 2019 - pubs.rsc.org
Bioconjugates are multifunctional constructs in which biomolecules like peptides, proteins,
vitamins and nucleic acids are endowed with the properties of specific payloads. These …

Boron in drug design: Recent advances in the development of new therapeutic agents

GFS Fernandes, WA Denny, JL Dos Santos - European journal of medicinal …, 2019 - Elsevier
Advances in the field of boron chemistry have expanded the application of this element in
Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …

Reactive oxygen species (ROS)-responsive prodrugs, probes, and theranostic prodrugs: applications in the ROS-related diseases

P Wang, Q Gong, J Hu, X Li… - Journal of medicinal …, 2020 - ACS Publications
Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …

Cross-coupling of heteroatomic electrophiles

KM Korch, DA Watson - Chemical reviews, 2019 - ACS Publications
At the advent of cross-coupling chemistry, carbon electrophiles based on halides or
pseudohalides were the only suitable electrophilic coupling partners. Almost two decades …

Carboxylic acid (bio) isosteres in drug design

C Ballatore, DM Huryn, AB Smith III - ChemMedChem, 2013 - Wiley Online Library
The carboxylic acid functional group can be an important constituent of a pharmacophore,
however, the presence of this moiety can also be responsible for significant drawbacks …

Deaminative borylation of aliphatic amines enabled by visible light excitation of an electron donor–acceptor complex

F Sandfort, F Strieth‐Kalthoff… - … A European Journal, 2018 - Wiley Online Library
A deaminative strategy for the borylation of aliphatic primary amines is described. Alkyl
radicals derived from the single‐electron reduction of redox‐active pyridinium salts, which …