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Photochemical and electrochemical applications of proton-coupled electron transfer in organic synthesis
We present here a review of the photochemical and electrochemical applications of multi-
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …
US FDA approved drugs from 2015–June 2020: a perspective
In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
First-row d-block element-catalyzed carbon–boron bond formation and related processes
SK Bose, L Mao, L Kuehn, U Radius… - Chemical …, 2021 - ACS Publications
Organoboron reagents represent a unique class of compounds because of their utility in
modern synthetic organic chemistry, often affording unprecedented reactivity. The …
modern synthetic organic chemistry, often affording unprecedented reactivity. The …
Diboron (4) compounds: from structural curiosity to synthetic workhorse
Although known for over 90 years, only in the past two decades has the chemistry of diboron
(4) compounds been extensively explored. Many interesting structural features and reaction …
(4) compounds been extensively explored. Many interesting structural features and reaction …
Boronic acids as building blocks for the construction of therapeutically useful bioconjugates
JPM António, R Russo, CP Carvalho… - Chemical Society …, 2019 - pubs.rsc.org
Bioconjugates are multifunctional constructs in which biomolecules like peptides, proteins,
vitamins and nucleic acids are endowed with the properties of specific payloads. These …
vitamins and nucleic acids are endowed with the properties of specific payloads. These …
Boron in drug design: Recent advances in the development of new therapeutic agents
Advances in the field of boron chemistry have expanded the application of this element in
Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …
Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …
Reactive oxygen species (ROS)-responsive prodrugs, probes, and theranostic prodrugs: applications in the ROS-related diseases
P Wang, Q Gong, J Hu, X Li… - Journal of medicinal …, 2020 - ACS Publications
Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …
Cross-coupling of heteroatomic electrophiles
KM Korch, DA Watson - Chemical reviews, 2019 - ACS Publications
At the advent of cross-coupling chemistry, carbon electrophiles based on halides or
pseudohalides were the only suitable electrophilic coupling partners. Almost two decades …
pseudohalides were the only suitable electrophilic coupling partners. Almost two decades …
Carboxylic acid (bio) isosteres in drug design
The carboxylic acid functional group can be an important constituent of a pharmacophore,
however, the presence of this moiety can also be responsible for significant drawbacks …
however, the presence of this moiety can also be responsible for significant drawbacks …
Deaminative borylation of aliphatic amines enabled by visible light excitation of an electron donor–acceptor complex
A deaminative strategy for the borylation of aliphatic primary amines is described. Alkyl
radicals derived from the single‐electron reduction of redox‐active pyridinium salts, which …
radicals derived from the single‐electron reduction of redox‐active pyridinium salts, which …