Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
Strategies to overcome DC dysregulation in the tumor microenvironment
Dendritic cells (DCs) play a key role to modulate anti-cancer immunity in the tumor
microenvironment (TME). They link innate to adaptive immunity by processing and …
microenvironment (TME). They link innate to adaptive immunity by processing and …
Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics
The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-
immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now …
immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now …
Intratumoral tumor infiltrating lymphocytes (TILs) are associated with cell proliferation and better survival but not always with chemotherapy response in breast cancer
Objective: To investigate the clinical relevance of intratumoral tumor infiltrating lymphocytes
(TILs) in breast cancer as measured by computational deconvolution of bulk tumor …
(TILs) in breast cancer as measured by computational deconvolution of bulk tumor …
Enhanced epithelial-mesenchymal transition signatures are linked with adverse tumor microenvironment, angiogenesis and worse survival in gastric cancer
Epithelial-mesenchymal transition (EMT) is a crucial mechanism that facilitates cancer cell
metastasis. Despite its importance, the clinical significance of EMT in gastric cancer (GC) …
metastasis. Despite its importance, the clinical significance of EMT in gastric cancer (GC) …
Clinical relevance of stem cell surface markers CD133, CD24, and CD44 in colorectal cancer
Colon cancer stem cells (CSC) identified by cell surface markers CD133, CD24, and CD44,
have been shown to be involved with tumor formation, chemotherapy resistance, and the …
have been shown to be involved with tumor formation, chemotherapy resistance, and the …
Impact of the Cancer Cell Secretome in driving breast Cancer progression
Simple Summary Breast cancer is a complex disease that remains a significant public health
challenge. The breast cancer cells secrete various substances collectively known as the …
challenge. The breast cancer cells secrete various substances collectively known as the …
G2M checkpoint pathway alone is associated with drug response and survival among cell proliferation-related pathways in pancreatic cancer
Given the severe side effects of the treatments and poor survival, prognostic and predictive
biomarkers to guide management of pancreatic cancer are in critical need. We hypothesized …
biomarkers to guide management of pancreatic cancer are in critical need. We hypothesized …
Role of hypoxia in inhibiting dendritic cells by VEGF signaling in tumor microenvironments: mechanism and application
The tumor microenvironment (TME) plays a central role in tumor initiation, development,
immune escape, and clinical treatment. Hypoxia, an important characteristic of the TME …
immune escape, and clinical treatment. Hypoxia, an important characteristic of the TME …
Tumor‐associated human dendritic cell subsets: Phenotype, functional orientation, and clinical relevance
DCs play a pivotal role in orchestrating innate and adaptive antitumor immunity. Activated
DCs can produce large amounts of various proinflammatory cytokines, initiate T‐cell …
DCs can produce large amounts of various proinflammatory cytokines, initiate T‐cell …