Production, purification and availability of 211At: Near term steps towards global access

Y Feng, MR Zalutsky - Nuclear medicine and biology, 2021 - Elsevier
The promising characteristics of the 7.2-h radiohalogen 211 At have long been recognized;
including having chemical properties suitable for labeling targeting vectors ranging from …

Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals

F Li, Y Yang, J Liao, N Liu - Chinese Chemical Letters, 2022 - Elsevier
Abstract Astatine-211 (211 At, t 1/2= 7.21 h) emitting two α particles with energies of 5.87
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …

A new type of halogen bond involving multivalent astatine: an ab initio study

F Zhou, Y Liu, Z Wang, T Lu, Q Yang, Y Liu… - Physical Chemistry …, 2019 - pubs.rsc.org
Theoretical studies on the dimers formed by CO with the halides of multivalent astatine as a
Lewis-acid center are carried out to examine the typical characteristics of supervalent …

211 At-labeled immunoconjugate via a one-pot three-component double click strategy: practical access to α-emission cancer radiotherapeutics

K Fujiki, Y Kanayama, S Yano, N Sato, T Yokokita… - Chemical …, 2019 - pubs.rsc.org
α-Emission radiotherapeutics has potential to be one of most effective cancer therapeutics.
Herein, we report a facile synthesis of an 211At-labeled immunoconjugate for use as an α …

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V di Iorio, A Sarnelli, A Milano, RM Genovese, R Miko… - enen.eu
The document comprehensively reviews the clinical applications and future potential of
alpha-emitting radionuclides in cancer treatment. It highlights the advantages of alpha …