Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component
of a wide range of cellular and gene therapies. Recent efforts have achieved> 200‐fold …

Gene editing the BCL11A erythroid enhancer is a validated approach to fetal hemoglobin
(HbF) induction for β-hemoglobinopathy therapy, though heterogeneity in edit allele …

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-
renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate …

Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and
its long-term integrity. Although regulation of stress responses incurred as a result of HSC …

Abstract Purpose of Review Hematopoietic stem cells (HSCs) maintain blood and immune
cell homeostasis by balancing quiescence, self-renewal, and differentiation. HSCs can be …

Simple Summary Transplantation of adult hematopoietic stem cells is an important
therapeutic tool to help patients suffering from diverse hematological disorders. All types of …

Haematopoietic stem cells are the basis for building and maintaining lifelong
haematopoietic mechanisms and an important resource for the treatment of blood disorders …

Adult hematopoietic stem cells (HSCs) are responsible for the lifelong production of blood
and immune cells, a process regulated by extracellular cues, including cytokines. Many …