Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

AC Dolphin - Nature Reviews Neuroscience, 2012 - nature.com
The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …

The β Subunit of Voltage-Gated Ca2+ Channels

Z Buraei, J Yang - Physiological reviews, 2010 - journals.physiology.org
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

[PDF][PDF] Structure and function of voltage-gated ion channels

WA Catterall - Annual review of biochemistry, 1995 - perso.univ-rennes1.fr
The voltage-gated sodium, calcium, and potassium channels are responsible for the
generation of conducted electrical signals in neurons and other excitable cells. The …

Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit

M Pragnell, M De Waard, Y Mori, T Tanabe, TP Snutch… - Nature, 1994 - nature.com
THE β-subunit is an integral component of purified voltage-sensitive Ca2+ channels1–3.
Modulation of Ca2+ channel activity by the β-subunit, which includes significant increases in …

Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit

J Rettig, SH Heinemann, F Wunder, C Lorra, DN Parcej… - Nature, 1994 - nature.com
Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain
is enhanced by the association of two different types of subunits, the membrane-bound, pore …

A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling

T Muta, T Kurosaki, Z Misulovin, M Sanchez… - Nature, 1994 - nature.com
THE Fc receptor on B lymphocytes, FcγRIIB (β1 isoform), helps to modulate B-cell activation
triggered by the surface immunoglobulin complex1, 2. Crosslinking of membrane …

The role of Ca2+ ions in excitation-contraction coupling of skeletal muscle fibres

W Melzer, A Herrmann-Frank, HC Lüttgau - Biochimica et Biophysica Acta …, 1995 - Elsevier
When a vertebrate skeletal muscle fibre is activated by a nerve impulse, an action potential
spreads from the endplate region along the whole fibre. It enters the transverse tubular …

Auxiliary subunits of voltage-gated ion channels

LL Isom, KS De Jongh, WA Catterall - Neuron, 1994 - Elsevier
The voltage-gated Na+, Ca*+, and K+ channels are responsible for the generation of action
potentials in neurons and other excitable cells. These channels are also involved in cellular …

The I-II loop of the Ca2+ channel α1 subunit contains an endoplasmic reticulum retention signal antagonized by the β subunit

D Bichet, V Cornet, S Geib, E Carlier, S Volsen, T Hoshi… - Neuron, 2000 - cell.com
The auxiliary β subunit is essential for functional expression of high voltage-activated Ca 2+
channels. This effect is partly mediated by a facilitation of the intracellular trafficking of α 1 …

The role of voltage-gated calcium channels in pancreatic β-cell physiology and pathophysiology

SN Yang, PO Berggren - Endocrine reviews, 2006 - academic.oup.com
Voltage-gated calcium (CaV) channels are ubiquitously expressed in various cell types
throughout the body. In principle, the molecular identity, biophysical profile, and …