Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …

HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …

Abstract Human immunodeficiency virus 1 (HIV-1) reservoir cells persist lifelong despite
antiretroviral treatment, but may be vulnerable to host immune responses that could be …

Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing
CD8+ T cell functions, which requires a deeper understanding of CD8+ T cells promoting …

Chimeric antigen receptors (CARs) have shown remarkable ability to re-direct T cells to
target CD19-expressing tumours, resulting in remission rates of up to 90% in individuals with …

Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune
response to cancer. Thus, induction of their activity is the ultimate aim of all …

Current paradigms of CD8+ T cell–mediated protection in HIV infection center almost
exclusively on studies of peripheral blood, which is thought to provide a window into …

COVID-19 is an infectious disease caused by the coronavirus SARS-CoV-2, which was first
reported in Wuhan, China, in December 2019 and has caused a global pandemic. Acute …

Nearly 2.3 million individuals worldwide are coinfected with human immunodeficiency virus
(HIV) and hepatitis C virus (HCV). Odds of HCV infection are six times higher in people living …