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Signaling pathways and therapeutic interventions in gastric cancer
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …
Despite tremendous progress in diagnosis and therapeutic strategies and significant …
[HTML][HTML] TGFβ in cancer
J Massagué - cell, 2008 - cell.com
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan
biology, and its misregulation can result in tumor development. The regulatory cytokine …
biology, and its misregulation can result in tumor development. The regulatory cytokine …
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
The steroid hormone estrogen regulates many functionally unrelated processes in
numerous tissues. Although it is traditionally thought to control transcriptional activation …
numerous tissues. Although it is traditionally thought to control transcriptional activation …
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis
MM Moasser - Oncogene, 2007 - nature.com
The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …
Signaling cross-talk between TGF-β/BMP and other pathways
X Guo, XF Wang - Cell research, 2009 - nature.com
Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is
involved in the vast majority of cellular processes and is fundamentally important during the …
involved in the vast majority of cellular processes and is fundamentally important during the …
Molecular requirements for epithelial–mesenchymal transition during tumor progression
MA Huber, N Kraut, H Beug - Current opinion in cell biology, 2005 - Elsevier
Epithelial–mesenchymal transitions (EMTs) occur as key steps during embryonic
morphogenesis, and are now implicated in the progression of primary tumors towards …
morphogenesis, and are now implicated in the progression of primary tumors towards …
LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer
SJ Shi, LJ Wang, B Yu, YH Li, Y **, XZ Bai - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
Trastuzumab resistance is leading cause of mortality in HER2-positive breast cancers, and
the role of TGF-β-induced epithelial-mesenchymal transition (EMT) in trastuzumab …
the role of TGF-β-induced epithelial-mesenchymal transition (EMT) in trastuzumab …
[HTML][HTML] Mutant p53 drives invasion by promoting integrin recycling
Summary p53 is a tumor suppressor protein whose function is frequently lost in cancers
through missense mutations within the Tp53 gene. This results in the expression of point …
through missense mutations within the Tp53 gene. This results in the expression of point …
Modelling glandular epithelial cancers in three-dimensional cultures
Little is known about how the genotypic and molecular abnormalities associated with
epithelial cancers actually contribute to the histological phenotypes observed in tumours in …
epithelial cancers actually contribute to the histological phenotypes observed in tumours in …
V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway
Tumors with mutant BRAF and those with receptor tyrosine kinase (RTK) activation have
similar levels of phosphorylated ERK, but only the former depend on ERK signaling for …
similar levels of phosphorylated ERK, but only the former depend on ERK signaling for …