Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y **e… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

[HTML][HTML] TGFβ in cancer

J Massagué - cell, 2008 - cell.com
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan
biology, and its misregulation can result in tumor development. The regulatory cytokine …

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

CM Revankar, DF Cimino, LA Sklar, JB Arterburn… - Science, 2005 - science.org
The steroid hormone estrogen regulates many functionally unrelated processes in
numerous tissues. Although it is traditionally thought to control transcriptional activation …

The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis

MM Moasser - Oncogene, 2007 - nature.com
The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …

Signaling cross-talk between TGF-β/BMP and other pathways

X Guo, XF Wang - Cell research, 2009 - nature.com
Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is
involved in the vast majority of cellular processes and is fundamentally important during the …

Molecular requirements for epithelial–mesenchymal transition during tumor progression

MA Huber, N Kraut, H Beug - Current opinion in cell biology, 2005 - Elsevier
Epithelial–mesenchymal transitions (EMTs) occur as key steps during embryonic
morphogenesis, and are now implicated in the progression of primary tumors towards …

LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer

SJ Shi, LJ Wang, B Yu, YH Li, Y **, XZ Bai - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
Trastuzumab resistance is leading cause of mortality in HER2-positive breast cancers, and
the role of TGF-β-induced epithelial-mesenchymal transition (EMT) in trastuzumab …

[HTML][HTML] Mutant p53 drives invasion by promoting integrin recycling

PAJ Muller, PT Caswell, B Doyle, MP Iwanicki, EH Tan… - Cell, 2009 - cell.com
Summary p53 is a tumor suppressor protein whose function is frequently lost in cancers
through missense mutations within the Tp53 gene. This results in the expression of point …

Modelling glandular epithelial cancers in three-dimensional cultures

J Debnath, JS Brugge - Nature Reviews Cancer, 2005 - nature.com
Little is known about how the genotypic and molecular abnormalities associated with
epithelial cancers actually contribute to the histological phenotypes observed in tumours in …

V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway

CA Pratilas, BS Taylor, Q Ye, A Viale, C Sander… - Proceedings of the …, 2009 - pnas.org
Tumors with mutant BRAF and those with receptor tyrosine kinase (RTK) activation have
similar levels of phosphorylated ERK, but only the former depend on ERK signaling for …