Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …

Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

ABSTRACT A recent Perspective article described the “carbohydrate-insulin model (CIM)” of
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …

According to a commonly held view, the obesity pandemic is caused by overconsumption of
modern, highly palatable, energy-dense processed foods, exacerbated by a sedentary …

The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …

For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

Westernized populations are plagued by a plethora of chronic non-infectious degenerative
diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases …

Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic β-cells (or β-
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …

Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

Alzheimer's disease (AD) is the main type of dementia and is a disease with a profound
socioeconomic burden due to the lack of effective treatment. In addition to genetics and …