Macromolecules can gain special properties by adopting knotted conformations, but
engineering knotted macromolecules is a challenging task. Here, we unexpectedly find that …

All life forms are miraculous, but some are more inexplicable than others. Trypanosomes are
by far one of the most puzzling organisms on Earth: their mitochondrial genome, also called …

The 21st century has witnessed a revolutionary shift in the understanding of properties of
matter driven by the application of topological principles. While the traditional approach to …

Loop extrusion is one of the main processes sha** chromosome organization across the
cell cycle, yet its role in regulating deoxyribonucleic acid (DNA) entanglement and …

Polymers are an effective test bed for studying topological constraints in condensed matter
due to a wide array of synthetically available chain topologies. When linear and ring …

Understanding the relationship between the microscopic structure and topology of a material
and its macroscopic properties is a fundamental challenge across a wide range of systems …

Knotted proteins are present in nature, but there is still an open issue regarding the
existence of a universal role for these remarkable structures. To address this question, we …

In frustrated spin systems, creation and annihilation of topological defects are processes that
are hard to characterize and information about them is often extracted by measuring …

We investigate the rheology of ring copolymers theoretically within the framework of the
optimized Rouse–Zimm theory in dilute solutions. The ring copolymer is composed of two …

We explore the effect of Couette flow on knotted linear polymer chains with extensive
molecular dynamics simulations. Hydrodynamic interactions are accounted for using multi …