An important challenge during the COVID-19 pandemic has been to understand
asymptomatic disease and the extent to which this may be a source of transmission. As …

Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …

While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected individuals are …

Identifying the epitope of an antibody is a key step in understanding its function and its
potential as a therapeutic. Sequence-based clonal clustering can identify antibodies with …

Understanding the molecular mechanisms of coronavirus disease 2019 (COVID-19)
pathogenesis and immune response is vital for develo** therapies. Single-cell RNA …

Single-cell sequencing of RNA (scRNA-seq) has advanced our understanding of cellular
heterogeneity and signaling in developmental biology and disease. A large number of …

B cells play an essential role in adaptive immunity and are intimately correlated with
pleiotropic immune-mediated diseases. Each B cell occupies a unique B cell receptor …

Antibodies are vital proteins offering robust protection for the human body from pathogens.
The development of general protein and antibody-specific pre-trained language models …

Adaptive immunity's success relies on the extraordinary diversity of protein receptors on B
and T cell membranes. Despite this diversity, the existence of public receptors shared by …

Dynamic changes of the paired heavy and light chain B cell receptor (BCR) repertoire
provide an essential insight into understanding the humoral immune response post-SARS …