Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Repetitive brain trauma is associated with a progressive neurological deterioration, now
termed as chronic traumatic encephalopathy (CTE). Most instances of CTE occur in …

Tauopathies are clinically, morphologically and biochemically heterogeneous
neurodegenerative diseases characterized by the deposition of abnormal tau protein in the …

Background Persistent neuropsychiatric sequelae may develop in military personnel who
are exposed to combat; such sequelae have been attributed in some cases to chronic …

Diagnostic and prognostic biomarkers for mild traumatic brain injury (TBI), also known as
concussion, remain a major unmet clinical need. Moderate to severe TBI can be diagnosed …

BACKGROUND AND PURPOSE The recognition and management of concussion in sport is
an evolving and controversial topic with a myriad of groups and organizations producing …

Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD)
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …