Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies
Abstract Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are
collectively known as gelatinases whereas MMP-2 is gelatinase-A and MMP-9 is termed as …
collectively known as gelatinases whereas MMP-2 is gelatinase-A and MMP-9 is termed as …
[HTML][HTML] A narrative review of central nervous system involvement in acute leukemias
D Deak, N Gorcea-Andronic, V Sas… - Annals of …, 2021 - ncbi.nlm.nih.gov
Acute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each
year more successful therapies are implemented. However, in a subset of cases the overall …
year more successful therapies are implemented. However, in a subset of cases the overall …
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies
M Ruella, DM Barrett, SS Kenderian… - The Journal of …, 2016 - Am Soc Clin Investig
Potent CD19-directed immunotherapies, such as chimeric antigen receptor T cells (CART)
and blinatumomab, have drastically changed the outcome of patients with …
and blinatumomab, have drastically changed the outcome of patients with …
Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: recent progress and applications
D Ito, AM Frantz, JF Modiano - Veterinary immunology and …, 2014 - Elsevier
The term “lymphoma” describes a heterogeneous group of disorders involving monoclonal
proliferation of malignant lymphocytes. As a group, lymphomas are among the most …
proliferation of malignant lymphocytes. As a group, lymphomas are among the most …
A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1
M Numata, N Haginoya, M Shiroishi, T Hirata… - Cancer Cell …, 2023 - Springer
Background Mixed lineage leukemia 1-rearranged (MLL1-r) acute leukemia patients
respond poorly to currently available treatments and there is a need to develop more …
respond poorly to currently available treatments and there is a need to develop more …
Acute lymphoblastic leukaemia
L Pagliaro, SJ Chen, D Herranz, C Mecucci… - Nature Reviews …, 2024 - nature.com
Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …
Hematopoietic and chronic myeloid leukemia stem cells: multi-stability versus lineage restriction
G Brown - International Journal of Molecular Sciences, 2022 - mdpi.com
There is compelling evidence to support the view that the cell-of-origin for chronic myeloid
leukemia is a hematopoietic stem cell. Unlike normal hematopoietic stem cells, the progeny …
leukemia is a hematopoietic stem cell. Unlike normal hematopoietic stem cells, the progeny …
Hedgehog signaling in cancer stem cells: a focus on hematological cancers
V Campbell, M Copland - Stem cells and cloning: advances and …, 2015 - Taylor & Francis
The stem cell paradigm was first demonstrated in hematopoietic stem cells. Whilst classically
it was cytokines and chemokines which were believed to control stem cell fate, more recently …
it was cytokines and chemokines which were believed to control stem cell fate, more recently …
Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding
ME Belderbos, T Koster, B Ausema… - Blood, The Journal …, 2017 - ashpublications.org
Genetic and phenotypic heterogeneity of human leukemia is thought to drive leukemia
progression through a Darwinian process of selection and evolution of increasingly …
progression through a Darwinian process of selection and evolution of increasingly …
Flow cytometric quantification and immunophenoty** of leukemic stem cells in acute myeloid leukemia
K Hwang, CJ Park, S Jang, HS Chi, DY Kim, JH Lee… - Annals of …, 2012 - Springer
Leukemic stem cells (LSCs) are root of clonal growth in acute myeloid leukemia (AML) and
responsible for the propagation of leukemic blasts (LBs). LSCs are considered as CD34+ …
responsible for the propagation of leukemic blasts (LBs). LSCs are considered as CD34+ …