Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

The swift rise in acceptance of molecular principles defining phase separation by a broad
array of scientific disciplines is shadowed by increasing discoveries linking phase …

Central to Alzheimer's disease (AD) is the assembly of the amyloid‐beta peptide (Aβ) into
fibrils. A reduction in pH accompanying inflammation or subcellular compartments, may …

Gene therapy via retroviral vectors holds great promise for treating a variety of serious
diseases. It requires the use of additives to boost infectivity. Amyloid-like peptide nanofibers …

In acidic secretory granules of mammalian cells, peptide hormones including the parathyroid
hormone are presumably stored in the form of functional amyloid fibrils. Mature PTH …

Amyloid fibrils, crystal-like fibrillar aggregates of denatured proteins, are formed as a result
of the breakdown of supersaturation, causing a series of amyloidosis including Alzheimer's …

Abstract Alpha-synuclein (α-syn) aggregation and mitochondrial dysfunction are considered
as two of the main factors associated with Parkinson's disease (PD). In the present …

Amyloid fibril formation is associated with various amyloidoses, including
neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Amyloid fibrils …

The supersaturation of a solution refers to a non-equilibrium phase in which the solution is
trapped in a soluble state, even though the solute's concentration is greater than its …

Amyloid fibrils involved in amyloidoses are crystal-like aggregates, which are formed by
breaking supersaturation of denatured proteins. Ultrasonication is an efficient method of …