Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times.
They have enjoyed over 30 years of clinical usage and become essential tools in the …

Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Genomes of all living organisms are constantly threatened by endogenous and exogenous
agents that challenge the chemical integrity of DNA. Most bacteria have evolved a …

Antimicrobial efficacy, which is central to many aspects of medicine, is being rapidly eroded
by bacterial resistance. Since new resistance can be induced by antimicrobial action, highly …

Antibiotic resistance is one of the major challenges facing modern medicine worldwide. The
past few decades have witnessed rapid progress in our understanding of the multiple factors …

Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial
infections. Both theory and experiments have suggested that persisters facilitate genetic …

Antibiotic resistance, prompted by the overuse of antimicrobial agents, may arise from a
variety of mechanisms, particularly horizontal gene transfer of virulence and antibiotic …

Antibiotics target essential cellular functions but bacteria can become resistant by acquiring
either exogenous resistance genes or chromosomal mutations. Resistance mutations …

The antibiotic ciprofloxacin is used extensively to treat a wide range of infections caused by
the opportunistic pathogen Pseudomonas aeruginosa. Due to its extensive use, the …

Antimicrobial resistant zoonotic pathogens present on food constitute a direct risk to public
health. Antimicrobial resistance genes in commensal or pathogenic strains form an indirect …