Toxicant-associated steatohepatitis
Hepatotoxicity is the most common organ injury due to occupational and environmental
exposures to industrial chemicals. A wide range of liver pathologies ranging from necrosis to …
exposures to industrial chemicals. A wide range of liver pathologies ranging from necrosis to …
Understanding environmental contaminants' direct effects on non-alcoholic fatty liver disease progression
LE Armstrong, GL Guo - Current environmental health reports, 2019 - Springer
Abstract Purpose of Review Environmental contaminants are considered one of the major
factors in the development and progression of NAFLD, the most common liver disease in the …
factors in the development and progression of NAFLD, the most common liver disease in the …
Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene …
F Al-Salman, N Plant - Toxicology and applied pharmacology, 2012 - Elsevier
The polychlorinated biphenyl group possesses high environmental persistence, leading to
bioaccumulation and a number of adverse effects in mammals. Whilst coplanar PCBs elicit …
bioaccumulation and a number of adverse effects in mammals. Whilst coplanar PCBs elicit …
[HTML][HTML] Alcoholic, nonalcoholic, and toxicant-associated steatohepatitis: mechanistic similarities and differences
S Joshi-Barve, I Kirpich, MC Cave, LS Marsano… - Cellular and molecular …, 2015 - Elsevier
Hepatic steatosis and steatohepatitis are common histologic findings that can be caused by
multiple etiologies. The three most frequent causes for steatosis/steatohepatitis are alcohol …
multiple etiologies. The three most frequent causes for steatosis/steatohepatitis are alcohol …
The role of AHR-inducible cytochrome P450s in metabolism of polyunsaturated fatty acids
O Hankinson - Drug metabolism reviews, 2016 - Taylor & Francis
Abstract The environmental pollutant 2, 3, 7, 8-tetrachlorodibenzo-ρ-dioxin (TCDD) is the
prototype of a large number of non-genotoxic carcinogens, dietary phytochemicals and …
prototype of a large number of non-genotoxic carcinogens, dietary phytochemicals and …
2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent aryl hydrocarbon receptor
agonist that elicits dose-dependent hepatic fat accumulation and inflammation that can …
agonist that elicits dose-dependent hepatic fat accumulation and inflammation that can …
Dietary Fat Is a Lipid Source in 2,3,7,8-Tetrachlorodibenzo-ρ-Dioxin (TCDD)-Elicited Hepatic Steatosis in C57BL/6 Mice
MM Angrish, BD Mets, AD Jones… - Toxicological …, 2012 - academic.oup.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-ρ-dioxin (TCDD) increases fatty acid (FA) transport
and FA levels resulting in hepatic steatosis in mice. Diet as a source of lipids was …
and FA levels resulting in hepatic steatosis in mice. Diet as a source of lipids was …
[HTML][HTML] Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure …
J Esteban, I Sánchez-Pérez, G Hamscher… - Reproductive …, 2021 - Elsevier
Young adult wild-type and aryl hydrocarbon receptor knockout (AHRKO) mice of both sexes
and the C57BL/6J background were exposed to 10 weekly oral doses of 2, 3, 7, 8 …
and the C57BL/6J background were exposed to 10 weekly oral doses of 2, 3, 7, 8 …
Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2, 3, 7, 8 tetrachlorodibenzo-p-dioxin) interact in a mixture and …
A Ambolet-Camoit, C Ottolenghi, A Leblanc, MJ Kim… - Biochimie, 2015 - Elsevier
Individuals, typically, are exposed to mixtures of environmental xenobiotics affecting multiple
organs and acting through different xenosensors and pathways in species and cell-type …
organs and acting through different xenosensors and pathways in species and cell-type …
Linking coregulated gene modules with polycyclic aromatic hydrocarbon-related cancer risk in the 3D human bronchial epithelium
Exposure to polycyclic aromatic hydrocarbons (PAHs) often occurs as complex chemical
mixtures, which are linked to numerous adverse health outcomes in humans, with cancer as …
mixtures, which are linked to numerous adverse health outcomes in humans, with cancer as …