Pyroptosis, metabolism, and tumor immune microenvironment
T Du, J Gao, P Li, Y Wang, Q Qi, X Liu… - Clinical and …, 2021 - Wiley Online Library
In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …
Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD
Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …
[HTML][HTML] The diagnostic approach to monogenic very early onset inflammatory bowel disease
HH Uhlig, T Schwerd, S Koletzko, N Shah… - Gastroenterology, 2014 - Elsevier
Patients with a diverse spectrum of rare genetic disorders can present with inflammatory
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …
Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease
Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
Multiple causal variants underlie genetic associations in humans
Associations between genetic variation and traits are often in noncoding regions with strong
linkage disequilibrium (LD), where a single causal variant is assumed to underlie the …
linkage disequilibrium (LD), where a single causal variant is assumed to underlie the …
BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis
R Roychoudhuri, K Hirahara, K Mousavi, D Clever… - Nature, 2013 - nature.com
Through their functional diversification, distinct lineages of CD4+ T cells can act to either
drive or constrain immune-mediated pathology. Transcription factors are critical in the …
drive or constrain immune-mediated pathology. Transcription factors are critical in the …
Therapeutic opportunities in inflammatory bowel disease: mechanistic dissection of host-microbiome relationships
The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …
complex interaction between host genetics, host immunity, microbiome, and environmental …
Pyroptosis in renal inflammation and fibrosis: current knowledge and clinical significance
Y Liu, H Lei, W Zhang, Q **ng, R Liu, S Wu, Z Liu… - Cell Death & …, 2023 - nature.com
Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …
Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease
HH Uhlig - Gut, 2013 - gut.bmj.com
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, has
multifactorial aetiology with complex interactions between genetic and environmental …
multifactorial aetiology with complex interactions between genetic and environmental …
Role of GSDMB in pyroptosis and cancer
L Li, Y Li, Y Bai - Cancer Management and Research, 2020 - Taylor & Francis
Gasdermin B (GSDMB) belongs to the gasdermin (GSDM) family which may adopt different
mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore …
mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore …