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G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
G protein βγ subunits: central mediators of G protein-coupled receptor signaling
AV Smrcka - Cellular and molecular life sciences, 2008 - Springer
G protein βγ subunits are central participants in G protein-coupled receptor signaling
pathways. They interact with receptors, G protein α subunits and downstream targets to …
pathways. They interact with receptors, G protein α subunits and downstream targets to …
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1
G-protein-coupled receptor (GPCR) kinases (GRKs) selectively phosphorylate activated
GPCRs, thereby priming them for desensitization. Although it is unclear how GRKs …
GPCRs, thereby priming them for desensitization. Although it is unclear how GRKs …
G protein-coupled receptor kinases: Past, present and future
This review is provided in recognition of the extensive contributions of Dr. Robert J.
Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday …
Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday …
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility
G protein-coupled receptor kinase 2 (GRK2) is a well-established therapeutic target for the
treatment of heart failure. Herein we identify the selective serotonin reuptake inhibitor (SSRI) …
treatment of heart failure. Herein we identify the selective serotonin reuptake inhibitor (SSRI) …
G protein-coupled receptor kinase 2 (GRK2) as a potential therapeutic target in cardiovascular and metabolic diseases
C Murga, AC Arcones, M Cruces-Sande… - Frontiers in …, 2019 - frontiersin.org
G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the
modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory …
modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory …
G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub
P Penela, C Ribas, F Sánchez-Madrid… - Cellular and Molecular …, 2019 - Springer
Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a
versatile protein that acts as a signaling hub by modulating G protein-coupled receptor …
versatile protein that acts as a signaling hub by modulating G protein-coupled receptor …
Paroxetine—overview of the molecular mechanisms of action
In the 21st century and especially during a pandemic, the diagnosis and treatment of
depression is an essential part of the daily practice of many family doctors. It mainly affects …
depression is an essential part of the daily practice of many family doctors. It mainly affects …
Atypical chemokine receptor 3 “senses” CXC chemokine receptor 4 activation through GPCR kinase phosphorylation
ABSTRACT Atypical chemokine receptor 3 (ACKR3) is an arrestin-biased receptor that
regulates extracellular chemokine levels through scavenging. The scavenging process …
regulates extracellular chemokine levels through scavenging. The scavenging process …
Self-masking in an intact ERM-merlin protein: an active role for the central α-helical domain
Ezrin/radixin/moesin (ERM) family members provide a regulated link between the cortical
actin cytoskeleton and the plasma membrane to govern membrane structure and …
actin cytoskeleton and the plasma membrane to govern membrane structure and …