Synthetic nanoparticles for vaccines and immunotherapy
The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …
Bio-inspired, bioengineered and biomimetic drug delivery carriers
Synthetic carriers such as polymer and lipid particles often struggle to meet clinical
expectations. Natural particulates—that range from pathogens to mammalian cells—are …
expectations. Natural particulates—that range from pathogens to mammalian cells—are …
Beyond antigens and adjuvants: formulating future vaccines
The need to optimize vaccine potency while minimizing toxicity in healthy recipients has
motivated studies of the formulation of vaccines to control how, when, and where antigens …
motivated studies of the formulation of vaccines to control how, when, and where antigens …
Polymeric nanoparticle vaccines to combat emerging and pandemic threats
D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …
West Nile Virus: biology, transmission, and human infection
TM Colpitts, MJ Conway… - Clinical microbiology …, 2012 - Am Soc Microbiol
SUMMARY West Nile Virus was introduced into the Western Hemisphere during the late
summer of 1999 and has been causing significant and sometimes severe human diseases …
summer of 1999 and has been causing significant and sometimes severe human diseases …
Engineering nano‐and microparticles to tune immunity
The immune system can be a cure or cause of disease, fulfilling a protective role in attacking
cancer or pathogenic microbes but also causing tissue destruction in autoimmune disorders …
cancer or pathogenic microbes but also causing tissue destruction in autoimmune disorders …
Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction
For subunit vaccines, adjuvants play a key role in sha** immunological memory.
Nanoparticle (NP) delivery systems for antigens and/or molecular danger signals are …
Nanoparticle (NP) delivery systems for antigens and/or molecular danger signals are …
Role of sustained antigen release from nanoparticle vaccines in sha** the T cell memory phenotype
SL Demento, W Cui, JM Criscione, E Stern, J Tulipan… - Biomaterials, 2012 - Elsevier
Particulate vaccines are emerging promising technologies for the creation of tunable
prophylactics against a wide variety of conditions. Vesicular and solid biodegradable …
prophylactics against a wide variety of conditions. Vesicular and solid biodegradable …
Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system
N Hanagata - International journal of nanomedicine, 2012 - Taylor & Francis
Unmethylated cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) are
recognized by Toll-like receptor 9 (TLR9) found in antigen-presenting cells and B cells and …
recognized by Toll-like receptor 9 (TLR9) found in antigen-presenting cells and B cells and …
Mucosal vaccine design and delivery
KA Woodrow, KM Bennett, DD Lo - Annual review of biomedical …, 2012 - annualreviews.org
Mucosal surfaces are a major portal of entry for many human pathogens that are the cause
of infectious diseases worldwide. Vaccines capable of eliciting mucosal immune responses …
of infectious diseases worldwide. Vaccines capable of eliciting mucosal immune responses …