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A brief history of amyloid aggregation simulations
Amyloid proteins are characterized by their tendency to aggregate into amyloid fibrils, which
are often associated with devastating diseases. Aggregation pathways typically involve …
are often associated with devastating diseases. Aggregation pathways typically involve …
Computational Investigation of Coaggregation and Cross-Seeding between Aβ and hIAPP Underpinning the Cross-Talk in Alzheimer's Disease and Type 2 Diabetes
The coexistence of amyloid-β (Aβ) and human islet amyloid polypeptide (hIAPP) in the brain
and pancreas is associated with an increased risk of Alzheimer's disease (AD) and type 2 …
and pancreas is associated with an increased risk of Alzheimer's disease (AD) and type 2 …
Computational insights into the cross-talk between medin and Aβ: implications for age-related vascular risk factors in Alzheimer's disease
The aggregation of medin forming aortic medial amyloid is linked to arterial wall
degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are …
degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are …
Co-aggregation of α-synuclein with amyloid-β stabilizes β-sheet-rich oligomers and enhances the formation of β-barrels
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common
neurodegenerative diseases with markedly different pathological features of β-amyloid (Aβ) …
neurodegenerative diseases with markedly different pathological features of β-amyloid (Aβ) …
Molecular insights into the effects of F16L and F19L substitutions on the conformation and aggregation dynamics of human calcitonin
Human calcitonin (hCT) regulates calcium–phosphorus metabolism, but its amyloid
aggregation disrupts physiological activity, increases thyroid carcinoma risk, and hampers …
aggregation disrupts physiological activity, increases thyroid carcinoma risk, and hampers …
Unveiling medin folding and dimerization dynamics and conformations via atomistic discrete molecular dynamics simulations
Medin is a principal component of localized amyloid found in the vasculature of individuals
over 50 years old. Its amyloid aggregation has been linked to endothelial dysfunction and …
over 50 years old. Its amyloid aggregation has been linked to endothelial dysfunction and …
Computational insights into the aggregation mechanism and amyloidogenic core of aortic amyloid medin polypeptide
Medin amyloid, prevalent in the vessel walls of 97% of individuals over 50, contributes to
arterial stiffening and cerebrovascular dysfunction, yet our understanding of its aggregation …
arterial stiffening and cerebrovascular dysfunction, yet our understanding of its aggregation …
Deciphering the influence of Y12L and N17H substitutions on the conformation and oligomerization of human calcitonin
The abnormal aggregation of human calcitonin (hCT) hormone peptides impairs their
physiological function, leading to harmful immune responses and cytotoxicity, which limits …
physiological function, leading to harmful immune responses and cytotoxicity, which limits …
Polystyrene Nanoplastics Hitch-Hike the Gut–Brain Axis to Exacerbate Parkinson's Pathology
X Liang, G Huang, Y Wang, N Andrikopoulos, H Tang… - ACS …, 2025 - ACS Publications
The neurological implications of micro-and nanoplastic exposure have recently come under
scrutiny due to the environmental prevalence of these synthetic materials. Parkinson's …
scrutiny due to the environmental prevalence of these synthetic materials. Parkinson's …
Exploring the Impact of Physiological C-Terminal Truncation on α-Synuclein Conformations to Unveil Mechanisms Regulating Pathological Aggregation
Emerging evidence suggests that physiological C-terminal truncation of α-synuclein (αS)
plays a critical role in regulating liquid–liquid phase separation and promoting amyloid …
plays a critical role in regulating liquid–liquid phase separation and promoting amyloid …