Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

Nanozyme-mediated tumor catalytic therapy has recently garnered attention as a means of
destroying tumor cells and eliciting anti-tumor immune responses. Herein, a copper-doped …

Natural killer (NK) cells are the prototype innate lymphoid cells endowed with potent cytolytic
function that provide host defence against microbial infection and tumours. Here, we review …

The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on
the cell surface, which provided the immune system with the signal to detect and eliminate …

Cytokines were the first modern immunotherapies to produce durable responses in patients
with advanced cancer, but they have only modest efficacy and limited tolerability,. In an effort …

Major histocompatibility complex (MHC) class I antigen presentation deficiency is a common
cancer immune escape mechanism, but the mechanistic implications and potential …

Local immunotherapy ideally stimulates immune responses against tumors while avoiding
toxicities associated with systemic administration. Current strategies for tumor-targeted …

Highlights•Tumor immune escape compromises the efficacy of cancer immunotherapy.•Loss
of MHC class I expression is a frequent event in cancer cells.•Three tumor phenotypes …

Immunological memory can be defined as a quantitatively and qualitatively enhanced
immune response upon rechallenge. For natural killer (NK) cells, two main types of memory …