Purpose: This review evaluates the role of dose rate on cell and molecular responses. It
focuses on the influence of dose rate on key events in critical pathways in the development …

Cancer patients receiving radiation therapy are exposed to photon (gamma/X-ray), electron,
and less commonly proton radiation. Similarly, astronauts on exploratory missions will be …

Background Genetically engineered mouse models (GEMMs) of cancer are powerful tools to
study mechanisms of disease progression and therapy response, yet little is known about …

The major goal of part I of this study was to compare varying doses and dose rates of whole-
body gamma-radiation on lymphoid cells and organs. C57BL/6 mice (n= 75) were exposed …

Bone loss associated with microgravity unloading is well documented; however, the effects
of spaceflight-relevant types and doses of radiation on the skeletal system are not well …

Although the immune system is highly susceptible to radiation-induced damage,
consequences of high linear energy transfer (LET) radiation remain unclear. This study …

Exposure to total-body radiation induces hematological changes, which can detriment one's
immune response to wounds and infection. Here, the decreases in blood cell counts after …

Space radiation represents a significant health risk for astronauts. Ground-based animal
studies indicate that space radiation affects neuronal functions such as excitability, synaptic …

There are several aspects of the spaceflight environment that may lead to changes in
immunity: mission-related psychological stress, radiation, and changes in gravity. On …

Abstract Bandstra, ER, Pecaut, MJ, Anderson, ER, Willey, JS, De Carlo, F., Stock, SR,
Gridley, DS, Nelson, GA, Levine, HG and Bateman, TA Long-Term Dose Response of …