The host-adapted human pathogen Neisseria gonorrhoeae is the causative agent of
gonorrhoea. Consistent with its proposed evolution from an ancestral commensal bacterium …

In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …

Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …

Genotype-to-phenotype map** commonly focuses on two major classes of mutations:
single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we …

Single-molecule real-time (SMRT) DNA sequencing allows the systematic detection of
chemical modifications such as methylation but has not previously been applied on a …

Epigenetics modulates expression levels of various important genes in both prokaryotes and
eukaryotes. These epigenetic traits are heritable without any change in genetic DNA …

The discovery of antibiotics in the last century is considered one of the most important
achievements in the history of medicine. Antibiotic usage has significantly reduced morbidity …

Growing resistance of pathogenic bacteria and shortage of antibiotic discovery platforms
challenge the use of antibiotics in the clinic. This threat calls for exploration of …

The amount of bacterial and archaeal genome sequence and methylome data has greatly
increased over the last decade, enabling new insights into the functional roles of DNA …

The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment
has led to a significant issue with pathogen resistance worldwide over the past decades …