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Hypoxic pulmonary vasoconstriction
JT Sylvester, LA Shimoda, PI Aaronson… - Physiological …, 2012 - journals.physiology.org
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
Acute oxygen-sensing mechanisms
This review discusses recent advances in the understanding of the ways in which different
organs detect and respond to acute changes in oxygen tension. A group of specialized …
organs detect and respond to acute changes in oxygen tension. A group of specialized …
Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension
M Mandegar, YCB Fung, W Huang, CV Remillard… - Microvascular …, 2004 - Elsevier
Pulmonary artery vasoconstriction and vascular remodeling greatly contribute to a sustained
elevation of pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP) in …
elevation of pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP) in …
Hypoxic pulmonary vasoconstriction: mechanisms and controversies
PI Aaronson, TP Robertson, GA Knock… - The Journal of …, 2006 - Wiley Online Library
The pulmonary circulation differs from the systemic in several important aspects, the most
important being that pulmonary arteries constrict to moderate physiological (∼ 20–60 mmHg …
important being that pulmonary arteries constrict to moderate physiological (∼ 20–60 mmHg …
Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells
Hypoxic pulmonary vasoconstriction (HPV) is a widely-conserved mechanism for matching
ventilation and perfusion that optimizes systemic PO2. HPV is elicited by moderate alveolar …
ventilation and perfusion that optimizes systemic PO2. HPV is elicited by moderate alveolar …
Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing
GB Waypa, PT Schumacker - Journal of applied physiology, 2005 - journals.physiology.org
Recently, the mitochondria have become the focus of attention as the site of O2 sensing
underlying hypoxic pulmonary vasoconstriction (HPV). However, two disparate models have …
underlying hypoxic pulmonary vasoconstriction (HPV). However, two disparate models have …
Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor
RM Leach, HM Hill, VA Snetkov… - The Journal of …, 2001 - Wiley Online Library
1 The mechanisms responsible for sensing hypoxia and initiating hypoxic pulmonary
vasoconstriction (HPV) are unclear. We therefore examined the roles of the mitochondrial …
vasoconstriction (HPV) are unclear. We therefore examined the roles of the mitochondrial …
Acute hypoxia increases intracellular [Ca2+] in pulmonary arterial smooth muscle by enhancing capacitative Ca2+ entry
Hypoxic pulmonary vasoconstriction (HPV) requires influx of extracellular Ca2+ in
pulmonary arterial smooth muscle cells (PASMCs). To determine whether capacitative Ca2+ …
pulmonary arterial smooth muscle cells (PASMCs). To determine whether capacitative Ca2+ …
Voltage‐independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat
TP Robertson, D Hague, PI Aaronson… - The journal of …, 2000 - Wiley Online Library
1 It has been proposed that hypoxic pulmonary vasoconstriction (HPV) is mediated via K+
channel inhibition and Ca2+ influx through voltage‐gated channels. HPV depends strongly …
channel inhibition and Ca2+ influx through voltage‐gated channels. HPV depends strongly …
Redox regulation of protein kinases as a modulator of vascular function
Reactive oxygen species (ROS) are continuously generated in vascular tissues by various
oxidoreductase enzymes. They contribute to normal cell signaling, and modulate vascular …
oxidoreductase enzymes. They contribute to normal cell signaling, and modulate vascular …