The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

The genome-wide program of gene expression during the cell division cycle in a human
cancer cell line (HeLa) was characterized using cDNA microarrays. Transcripts of> 850 …

Sexual reproduction relies on the fusion of paternal and maternal haploid gametes—the
sperm and the extremely large oocyte, respectively—forming a new diploid organism …

Mitotic spindle positioning by cortical pulling forces defines the cell division axis and
location, which is critical for proper cell division and development. Although recent work has …

The nuclear envelope (NE) is a highly regulated membrane barrier that separates the
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …

Macromolecular transport between the cytoplasm and the nucleus occurs through the
nuclear pore complex (NPC) and is mediated by multiple families of soluble transport …

Background Mass spectrometry-based proteomics enables the global identification and
quantification of proteins and their posttranslational modifications in complex biological …

Proteins of the karyopherin α and karyopherin β families play a central role in
nucleocytoplasmic transport. Recently, crystal structures of karyopherin α and its complexes …

Centrosomes of animal cells and spindle pole bodies of fungi are the major microtubule
nucleating centers. Recent studies indicate that their capacity to organize microtubule arrays …