Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

The immune system functions in a sexually dimorphic manner, with females exhibiting more
robust immune responses than males. However, how female sex hormones affect immune …

Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …

Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome
whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled …

Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

In addition to physical barriers, neutrophils are considered a part of the first line of immune
defense. They can be found in the bloodstream, with a lifespan of 6–8 h, and in tissue …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of
human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils …