Targeting p53 pathways: mechanisms, structures, and advances in therapy

H Wang, M Guo, H Wei, Y Chen - Signal transduction and targeted …, 2023 - nature.com
The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Cellular and molecular effects of non-ionizing electromagnetic fields

H Lai, BB Levitt - Reviews on environmental health, 2024 - degruyter.com
The way that living cells respond to non-ionizing electromagnetic fields (EMF), including
static/extremely-low frequency and radiofrequency electromagnetic fields, fits the pattern of …

Clinical significance of TP53 alterations in advanced NSCLC patients treated with EGFR, ALK and ROS1 tyrosine kinase inhibitors: An update

J Moes-Sosnowska, A Szpechcinski… - Tumor …, 2024 - journals.sagepub.com
The development of targeted therapies for non-small cell lung cancer (NSCLC), such as the
epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase …

From chaos to opportunity: decoding cancer heterogeneity for enhanced treatment strategies

A Ottaiano, M Ianniello, M Santorsola, R Ruggiero… - Biology, 2023 - mdpi.com
Simple Summary Cancer is a complex illness marked by aberrant cellular behaviors and
genetic variances, resulting in tumor heterogeneity that presents challenges in cancer …

Oligo-metastatic cancers: putative biomarkers, emerging challenges and new perspectives

A Ottaiano, M Santorsola, L Circelli, AM Trotta, F Izzo… - Cancers, 2023 - mdpi.com
Simple Summary Oligometastatic disease is a condition in oncology where cancer affects
only a few distant sites. It is associated with a low-burden spread and a more favorable …

Ubiquitination of GRK2 is required for the β-arrestin-biased signaling pathway of dopamine D2 receptors to activate ERK kinases

H Liu, H Ma, X Zeng, C Wu, S Acharya… - International journal of …, 2023 - mdpi.com
A class-A GPCR dopamine D2 receptor (D2R) plays a critical role in the proper functioning
of neuronal circuits through the downstream activation of both G-protein-and β-arrestin …

[HTML][HTML] The prognostic role of p53 mutations in metastatic colorectal cancer: A systematic review and meta-analysis

A Ottaiano, M Santorsola, M Capuozzo, F Perri… - Critical Reviews in …, 2023 - Elsevier
Introduction P53 is one of the most frequently mutated genes in colorectal cancer (CRC).
The present study was undertaken to provide a solid estimate of the prognostic value of p53 …

Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin

R Meidan, M Szymanska - Biology of Reproduction, 2023 - academic.oup.com
Abstract Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide–dependent deacetylase
that modifies gene expression through histone deacetylation. It also deacetylates …

The role of p53 in male infertility

J Li, X Huang, L Luo, J Sun, Q Guo, X Yang… - Frontiers in …, 2024 - frontiersin.org
The tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular
functions, including cell cycle arrest, DNA repair and apoptosis. Still, a growing number of …

Synthesis, characterization, and toxicity assessments of Silymarin-loaded Ni-Fe Metal-organic frameworks: Evidence from in vitro and in vivo evaluations

F Rahimi, S Shahraki, MR Ha**ezhad… - Journal of Drug Delivery …, 2024 - Elsevier
Multiple investigations indicated that Silymarin (Syl), a flavonolignan extracted from the
Silybum marianum plant, might possess anticancer properties. It is also advertised as a liver …