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[HTML][HTML] Molecular and clinical aspects of potential neurotoxicity induced by new psychoactive stimulants and psychedelics
New psychoactive stimulants and psychedelics continue to play an important role on the
illicit new psychoactive substance (NPS) market. Designer stimulants and psychedelics both …
illicit new psychoactive substance (NPS) market. Designer stimulants and psychedelics both …
Organic cation transporters in psychiatric and substance use disorders
Psychiatric and substance use disorders inflict major public health burdens worldwide. Their
widespread burden is compounded by a dearth of effective treatments, underscoring a dire …
widespread burden is compounded by a dearth of effective treatments, underscoring a dire …
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors
The presynaptic serotonin transporter (SERT) clears extracellular serotonin following
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …
Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties
P Puigseslloses, N Nadal-Gratacós, G Ketsela… - Molecular …, 2024 - nature.com
Recent studies have sparked renewed interest in the therapeutic potential of psychedelics
for treating depression and other mental health conditions. Simultaneously, the novel …
for treating depression and other mental health conditions. Simultaneously, the novel …
Persistent binding at dopamine transporters determines sustained psychostimulant effects
Psychostimulants interacting with the dopamine transporter (DAT) can be used illicitly or for
the treatment of specific neuropsychiatric disorders. However, they can also produce severe …
the treatment of specific neuropsychiatric disorders. However, they can also produce severe …
[HTML][HTML] A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational …
Dopamine (DA), the most abundant human brain catecholaminergic neurotransmitter,
modulates key behavioral and neurological processes in young and senescent brains …
modulates key behavioral and neurological processes in young and senescent brains …
Structure–Activity Relationship of Synthetic Cathinones: An Updated Review
The escalating prevalence of new psychoactive substances (NPSs) poses a significant
public health challenge, evidenced by the vast chemical diversity, with over 500 substances …
public health challenge, evidenced by the vast chemical diversity, with over 500 substances …
Bioisosteric analogs of MDMA: Improving the pharmacological profile?
Methylenedioxymethamphetamine (MDMA,'ecstasy') is re‐emerging in clinical settings as a
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …
Structure–Activity Relationship of N-Ethyl-Hexedrone Analogues: Role of the α-Carbon Side-Chain Length in the Mechanism of Action, Cytotoxicity, and Behavioral …
N Nadal-Gratacós, E Ríos-Rodríguez… - ACS Chemical …, 2023 - ACS Publications
Synthetic cathinones are β-keto amphetamine derivatives whose appearance has increased
dramatically in the past decades. N-Ethyl substituted cathinones have been proven to …
dramatically in the past decades. N-Ethyl substituted cathinones have been proven to …
Interaction profiles of central nervous system active drugs at human organic cation transporters 1–3 and human plasma membrane monoamine transporter
Many psychoactive compounds have been shown to primarily interact with high-affinity and
low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; …
low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; …