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BCL11A: a potential diagnostic biomarker and therapeutic target in human diseases
J Yin, X **e, Y Ye, L Wang, F Che - Bioscience reports, 2019 - portlandpress.com
Transcription factor B-cell lymphoma/leukemia 11A (BCL11A) gene encodes a zinc-finger
protein that is predominantly expressed in brain and hematopoietic tissue. BCL11A …
protein that is predominantly expressed in brain and hematopoietic tissue. BCL11A …
Targeting genetic modifiers of HBG gene expression in sickle cell disease: the miRNA option
A Starlard-Davenport, Q Gu, BS Pace - Molecular Diagnosis & Therapy, 2022 - Springer
Sickle cell disease (SCD) is one of the most common inherited hemoglobinopathy disorders
that affects millions of people worldwide. Reactivation of HBG (HBG1, HBG2) gene …
that affects millions of people worldwide. Reactivation of HBG (HBG1, HBG2) gene …
Role of microRNA in hydroxyurea mediated HbF induction in sickle cell anaemia patients
N Kargutkar, M Sawant-Mulay, P Hariharan… - Scientific Reports, 2023 - nature.com
Hydroxyurea (HU) is found to be beneficial in sickle cell anaemia (SCA) patients, due to its
ability to increase foetal haemoglobin (HbF), however, patients show a variable response …
ability to increase foetal haemoglobin (HbF), however, patients show a variable response …
MicroRNA expression patterns in HbE/β-thalassemia patients: The passwords to unlock fetal hemoglobin expression in β-hemoglobinopathies
Abstract Hemoglobin E (HbE)/β-thalassemia is a form of β-hemoglobinopathy that is well-
known for its clinical heterogeneity. Individuals suffering from this condition are often found …
known for its clinical heterogeneity. Individuals suffering from this condition are often found …
[HTML][HTML] Extracellular vesicle microRNA that are involved in β-thalassemia complications
Beta thalassemia major (βT) is a hereditary anemia characterized by transfusion-
dependency, lifelong requirement of chelation, and organ dysfunction. MicroRNA (miRNA) …
dependency, lifelong requirement of chelation, and organ dysfunction. MicroRNA (miRNA) …
Bioinformatic tools for the identification of MicroRNAs regulating the transcription factors in patients with β-thalassemia
SS Kalaigar, RB Rajashekar… - … and Biology Insights, 2022 - journals.sagepub.com
β-thalassemia is a significant health issue worldwide, with approximately 7% of the world's
population having defective hemoglobin genes. MicroRNAs (miRNAs) are short noncoding …
population having defective hemoglobin genes. MicroRNAs (miRNAs) are short noncoding …
The clinical value of hsa-miR-190b-5p in peripheral blood of pediatric β-thalassemia and its regulation on BCL11A expression
M Chen, X Wang, H Wang, M Zhang, L Chen, H Chen… - Plos one, 2023 - journals.plos.org
Background The B cell CLL/lymphoma 11A (BCL11A) is a key regulator of hemoglobin
switching in β-thalassemia (β-thal). Previous study has suggested that dysregulated …
switching in β-thalassemia (β-thal). Previous study has suggested that dysregulated …
MicroRNAs in β-thalassemia
F Wang, L Ling, D Yu - The American Journal of the Medical Sciences, 2021 - Elsevier
Abstract β-thalassemia is a lethal inherited disease resulting from β-globin gene mutations.
Severe β-thalassemia requires regular blood transfusions. Other active interventions …
Severe β-thalassemia requires regular blood transfusions. Other active interventions …
[HTML][HTML] Distinct miRNA signatures and networks discern fetal from adult erythroid differentiation and primary from immortalized erythroid cells
MicroRNAs (miRNAs) are small non-coding RNAs crucial for post-transcriptional and
translational regulation of cellular and developmental pathways. The study of miRNAs in …
translational regulation of cellular and developmental pathways. The study of miRNAs in …
PARP‐1 modulates the expression of miR‐223 through histone acetylation to involve in the hydroquinone‐induced carcinogenesis of TK6 cells
X Ling, Z Pan, H Zhang, M Wu, Z Gui… - … of Biochemical and …, 2022 - Wiley Online Library
The upstream regulators of microRNAs were rarely reported. Hydroquinone (HQ) is the main
metabolite of benzene, one of the important environmental factors contributing to leukemia …
metabolite of benzene, one of the important environmental factors contributing to leukemia …