High-density lipoprotein cholesterol level and risk of muscle strength decline and sarcopenia in older adults

N Hua, C Qin, F Wu, A Wang, J Chen, Q Zhang - Clinical Nutrition, 2024 - Elsevier
Background Recent studies have demonstrated that very high high-density lipoprotein
cholesterol (HDL-C) level was paradoxically linked with higher risk of cardiovascular …

Association between obesity, physical activity, and cognitive decline in Chinese middle and old-aged adults: a mediation analysis

X Xu, Y Xu, R Shi - BMC geriatrics, 2024 - Springer
Background and objectives Epidemiological evidence on obesity and cognitive decline in
middle and old-aged individuals is controversial and the effect of physical activity in this …

[HTML][HTML] Exploring the Dynamic Changes of Brain Lipids, Lipid Rafts, and Lipid Droplets in Aging and Alzheimer's Disease

M Cerasuolo, I Di Meo, MC Auriemma, G Paolisso… - Biomolecules, 2024 - mdpi.com
Aging induces complex changes in the lipid profiles across different areas of the brain.
These changes can affect the function of brain cells and may contribute to …

Cognitive impairment and depression precede increased HDL-C levels in middle-aged and older Chinese adults: cross-lagged panel analyses

YH Liu, MT Chen, YY He, M Chen, JR Liang… - Lipids in Health and …, 2024 - Springer
Background High-density lipoprotein cholesterol (HDL-C) is widely recognized for its
protective effects against cognitive decline. However, recent studies have presented …

Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals

Z Wu, L Cribb, R Wolfe, RC Shah… - JAMA Network …, 2025 - jamanetwork.com
Importance Poor cardiometabolic health is a risk factor associated with cognitive impairment
in later life, but it remains unclear whether cardiometabolic trajectories can serve as early …

Reevaluating elevated HDL cholesterol levels in healthy older persons as a risk factor for various disease states

RX Ji, ZY Duan - American journal of clinical and experimental …, 2024 - pmc.ncbi.nlm.nih.gov
This article reviews the role of high-density lipoprotein cholesterol (HDL-C) in the elderly
population, questioning the established view that advocates the ubiquitous health benefits of …

High-Fat Diet Augments Myocardial Inflammation and Cardiac Dysfunction in Arrhythmogenic Cardiomyopathy

AM Centner, EA Shiel, W Farra, EN Cannon… - Nutrients, 2024 - mdpi.com
Arrhythmogenic cardiomyopathy (ACM) is a familial heart disease characterized by cardiac
dysfunction, arrhythmias, and myocardial inflammation. Exercise and stress can influence …

The association of high-density lipoprotein cargo proteins with brain volume in older adults in the Atherosclerosis Risk in Communities (ARIC)

D Li, B An, L Men, M Glittenberg… - Journal of …, 2025 - journals.sagepub.com
Background High-density lipoprotein (HDL) modulates the blood-brain barrier and
cerebrovascular integrity, likely influencing the risk of Alzheimer's disease (AD) …

The association of cholesterol levels with memory and memory change over a 14‐year period in a US national cohort

S Miramontes, U Khan, EL Ferguson… - … Research & Clinical …, 2025 - Wiley Online Library
INTRODUCTION The impact of cholesterol on late‐life cognition remains controversial. We
investigated the association of high‐density lipoprotein cholesterol (HDL‐C) and non–HDL …

[HTML][HTML] Lipid measures are associated with cognitive functioning in multiple sclerosis patients

B Lőrincz, J Motýl, L Friedová, D Hrych… - Multiple Sclerosis and …, 2024 - Elsevier
Background An association between lipid measures and cognitive decline in patients with
multiple sclerosis (MS) has been suggested. Objectives This study aimed to investigate …