Idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis is a devastating, age-related lung disease of unknown cause
that has few treatment options. This disease was once thought to be a chronic inflammatory …
that has few treatment options. This disease was once thought to be a chronic inflammatory …
Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
MC Lampi, CA Reinhart-King - Science translational medicine, 2018 - science.org
Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and
cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical …
cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical …
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
PA Reyfman, JM Walter, N Joshi… - American journal of …, 2019 - atsjournals.org
Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
Diagnosis and evaluation of hypersensitivity pneumonitis: CHEST guideline and expert panel report
ERF Pérez, WD Travis, DA Lynch, KK Brown… - Chest, 2021 - Elsevier
Background The purpose of this analysis is to provide evidence-based and consensus-
derived guidance for clinicians to improve individual diagnostic decision-making for …
derived guidance for clinicians to improve individual diagnostic decision-making for …
Hypersensitivity pneumonitis: perspectives in diagnosis and management
Awareness of hypersensitivity pneumonitis (HP) as a unique disease entity dates back to the
18th century (1). Since then, numerous inciting agents have been attributed to inducing HP …
18th century (1). Since then, numerous inciting agents have been attributed to inducing HP …
Hypersensitivity pneumonitis: insights in diagnosis and pathobiology
Hypersensitivity pneumonitis (HP) is a complex syndrome resulting from repeated exposure
to a variety of organic particles. HP may present as acute, subacute, or chronic clinical forms …
to a variety of organic particles. HP may present as acute, subacute, or chronic clinical forms …
Hypersensitivity pneumonitis
Hypersensitivity pneumonitis (HP) is a complex syndrome caused by the inhalation of a
variety of antigens in susceptible and sensitized individuals. These antigens are found in the …
variety of antigens in susceptible and sensitized individuals. These antigens are found in the …
Immune mechanisms in pulmonary fibrosis
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and
progressive disease with high mortality and limited therapeutic options. Excessive …
progressive disease with high mortality and limited therapeutic options. Excessive …
Antifibrotic activities of pirfenidone in animal models
CJ Schaefer, DW Ruhrmund, L Pan… - European …, 2011 - Eur Respiratory Soc
Pirfenidone is an orally active small molecule that has recently been evaluated in large
clinical trials for the treatment of idiopathic pulmonary fibrosis, a fatal disease in which the …
clinical trials for the treatment of idiopathic pulmonary fibrosis, a fatal disease in which the …