CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …

Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

Intracellular delivery of advanced therapeutics, including biologicals and supramolecular
agents, is complex because of the natural biological barriers that have evolved to protect the …

Chimeric antigen receptor (CAR)‐T cell therapy has emerged as a promising cell‐based
immunotherapy approach for treating blood disorders and cancers, but genetically …

The plasma membrane (PM) is often described as a wall, a physical barrier separating the
cell cytoplasm from the extracellular matrix (ECM). Yet, this wall is a highly dynamic structure …

The start-ups taking nanoneedles into the clinic | Nature Nanotechnology Skip to main content
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The clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein
(Cas)(CRISPR/Cas) systems have recently emerged as powerful molecular biosensing tools …

Background Nanoinjection—the process of intracellular delivery using vertically configured
nanostructures—is a physical route that efficiently negotiates the plasma membrane, with …

Miniaturization is the trend to manufacture ever smaller devices and this process requires
knowledge, experience, understanding of materials, manufacturing techniques and scaling …

Electroporation (EP) is an effective and widely accepted intracellular delivery method for
fundamental research and medical applications. Existing electroporation methods usually …