Major depressive disorder (MDD), also referred to as depression, is one of the most common
psychiatric disorders with a high economic burden. The etiology of depression is still not …

Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

The psychedelic psilocybin is being investigated for the treatment of depression and anxiety.
Unclear is whether antidepressant treatments interact with psilocybin. The present study …

Introduction The heterogeneity of symptoms and complex etiology of depression pose a
significant challenge to the personalization of treatment. Meanwhile, the current application …

Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …

Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major
depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can …

Although schizophrenia is currently conceptualized as being characterized as a syndrome
that includes a collection of signs and symptoms, there is strong evidence of heterogeneous …

Exposure to early life stress (ELS) may lead to long-lasting neurobiological and behavioral
impairments. Alterations in the immune system and neuroinflammatory state induced by ELS …

Abstract Ethnopharmacological relevance Kai-**n-San (KXS) has been prescribed by TCM
doctors for treating psychiatric diseases with the core symptoms of anhedonia, amnesia, and …

Recommendations include using large prospective observational studies followed by
pragmatic trials rather than smaller, expensive controlled treatment trials for preliminary …