Sex differences in autism spectrum disorder: diagnostic, neurobiological, and behavioral features

A Napolitano, S Schiavi, P La Rosa… - Frontiers in …, 2022 - frontiersin.org
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a
worldwide prevalence of about 1%, characterized by impairments in social interaction …

Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

Altered gut microbiota and activity in a murine model of autism spectrum disorders

CGM De Theije, H Wopereis, M Ramadan… - Brain, behavior, and …, 2014 - Elsevier
Autism spectrum disorder (ASD) is a heterogeneous group of complex neurodevelopmental
disorders with evidence of genetic predisposition. Intestinal disturbances are reported in …

A systematic review of the valproic-acid-induced rodent model of autism

D Chaliha, M Albrecht, M Vaccarezza… - Developmental …, 2020 - karger.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by
repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment …

Exploring the validity of valproic acid animal model of autism

DFN Mabunga, ELT Gonzales, J Kim… - Experimental …, 2015 - pmc.ncbi.nlm.nih.gov
The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most
widely used animal model in the field. Like any other disease models, it can't model the …

Gut-brain axis: role of lipids in the regulation of inflammation, pain and CNS diseases

R Russo, C Cristiano, C Avagliano… - Current medicinal …, 2018 - ingentaconnect.com
The human gut is a composite anaerobic environment with a large, diverse and dynamic
enteric microbiota, represented by more than 100 trillion microorganisms, including at least …

Three decades of valproate: a current model for studying autism spectrum disorder

D Zarate-Lopez, AL Torres-Chávez… - Current …, 2024 - benthamdirect.com
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …

Sex‐specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling

F Melancia, S Schiavi, M Servadio… - British journal of …, 2018 - Wiley Online Library
Background and Purpose Autism spectrum disorder (ASD) is more commonly diagnosed in
males than in females. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is an …

Alterations in the endocannabinoid system in the rat valproic acid model of autism

DM Kerr, L Downey, M Conboy, DP Finn… - Behavioural brain …, 2013 - Elsevier
The endocannabinoid system plays a crucial role in regulating emotionality and social
behaviour, however it is unknown whether this system plays a role in symptoms associated …

Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder

G Park, WE Jang, S Kim, EL Gonzales, J Ji… - … & Molecular Medicine, 2023 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with impaired
social behavior and communication, repetitive behaviors, and restricted interests. In addition …