Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …

Understanding intratumoral heterogeneity—the molecular variation among cells within a
tumor—promises to address outstanding questions in cancer biology and improve the …

Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …

Pancreatic ductal adenocarcinoma (PDA) is characterized by an immune-suppressive tumor
microenvironment that renders it largely refractory to immunotherapy. We implemented a …

Importance PD-L1 (programmed cell death ligand 1) immunohistochemistry (IHC), tumor
mutational burden (TMB), gene expression profiling (GEP), and multiplex …

Antigen-specific CD8+ T cell accumulation in tumors is a prerequisite for effective
immunotherapy, and yet the mechanisms of lymphocyte transit are not well defined. Here we …

Abstract Digital Spatial Profiling (DSP) is a method for highly multiplex spatial profiling of
proteins or RNAs suitable for use on formalin-fixed, paraffin-embedded (FFPE) samples. The …