Many risk genes interact synergistically to produce schizophrenia and many
neurotransmitter interactions have been implicated. We have developed a circuit-based …

Until recently, the study of plasticity of neural circuits focused almost exclusively on
potentiation and depression at excitatory synapses on principal cells. Other elements in the …

Neurotransmitter corelease is emerging as a common theme of central neuromodulatory
systems. Though corelease of glutamate or GABA with acetylcholine has been reported …

Cholinergic modulation of hippocampal synaptic plasticity has been studied extensively by
applying receptor agonists or blockers; however, the effect of rapid physiological cholinergic …

Cholinergic septohippocampal projections from the medial septal area to the hippocampus
are proposed to have important roles in cognition by modulating properties of the …

Schizophrenia is considered primarily as a cognitive disorder. However, functional
outcomes in schizophrenia are limited by the lack of effective pharmacological and …

Alcoholism is a common, heritable, chronic relapsing disorder. GABAA receptors undergo
allosteric modulation by ethanol, anesthetics, benzodiazepines and neurosteroids and have …

Evidence supports inflammatory involvement in mood and cognitive symptoms across
psychiatric, neurological and medical disorders; however, inflammation is not a sensitive or …

The specific pharmacological response evoked by a nicotinic acetylcholine receptor
(nAChR) agonist is governed by the anatomical distribution and expression of each receptor …

This review attempts to organize the different aspects of nicotinic transmission in the context
of nonsynaptic interactions. Nicotinic acetylcholine receptors (nAChRs) dominantly operate …