Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

H Lu, Q Zhou, J He, Z Jiang, C Peng, R Tong… - Signal transduction and …, 2020 - nature.com
Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Hierarchical self-assembly into chiral nanostructures

Y Sang, M Liu - Chemical Science, 2022 - pubs.rsc.org
One basic principle regulating self-assembly is associated with the asymmetry of constituent
building blocks or packing models. Using asymmetry to manipulate molecular-level devices …

The mammalian blood-testis barrier: its biology and regulation

DD Mruk, CY Cheng - Endocrine reviews, 2015 - academic.oup.com
Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Molecular mechanisms of plant responses to salt stress

L Ma, X Liu, W Lv, Y Yang - Frontiers in Plant Science, 2022 - frontiersin.org
Saline-alkali soils pose an increasingly serious global threat to plant growth and
productivity. Much progress has been made in elucidating how plants adapt to salt stress by …

Alpha-synuclein structure, functions, and interactions

FN Emamzadeh - Journal of Research in Medical Sciences, 2016 - journals.lww.com
At present, when a clinical diagnosis of Parkinson's disease (PD) is made, serious damage
has already been done to nerve cells of the substantia nigra pars compacta. The diagnosis …

Critical role of transforming growth factor beta in different phases of wound healing

M Pakyari, A Farrokhi, MK Maharlooei… - Advances in wound …, 2013 - liebertpub.com
Significance: This review highlights the critical role of transforming growth factor beta (TGF-
β) 1–3 within different phases of wound healing, in particular, late-stage wound healing. It is …

[HTML][HTML] hERG K+ channels: structure, function, and clinical significance

JI Vandenberg, MD Perry, MJ Perrin… - Physiological …, 2012 - journals.physiology.org
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies

Z Li, AA Ivanov, R Su, V Gonzalez-Pecchi, Q Qi… - Nature …, 2017 - nature.com
As genomics advances reveal the cancer gene landscape, a daunting task is to understand
how these genes contribute to dysregulated oncogenic pathways. Integration of cancer …

[HTML][HTML] Curcumin and cardiovascular diseases: Focus on cellular targets and cascades

AM Pourbagher-Shahri, T Farkhondeh… - Biomedicine & …, 2021 - Elsevier
Cardiovascular diseases (CVDs) are one of the leading causes of the most considerable
mortality globally, and it has been tried to find the molecular mechanisms and design new …

The multifunctional fish gill: dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste

DH Evans, PM Piermarini, KP Choe - Physiological reviews, 2005 - journals.physiology.org
The fish gill is a multipurpose organ that, in addition to providing for aquatic gas exchange,
plays dominant roles in osmotic and ionic regulation, acid-base regulation, and excretion of …