[HTML][HTML] Development of novel experimental models to study flavoproteome alterations in human neuromuscular diseases: the effect of Rf therapy

M Tolomeo, A Nisco, P Leone, M Barile - International journal of …, 2020 - mdpi.com
Inborn errors of Riboflavin (Rf) transport and metabolism have been recently related to
severe human neuromuscular disorders, as resulting in profound alteration of human …

Structural insights into the bifunctional enzyme human FAD synthase

G Leo, P Leone, EA Kachoie, M Tolomeo, M Galluccio… - Structure, 2024 - cell.com
Human flavin adenine dinucleotide synthase (hFADS) is a bifunctional, multi-domain
enzyme that exhibits both flavin mononucleotide adenylyltransferase and pyrophosphatase …

Alteration of flavin cofactor homeostasis in human neuromuscular pathologies

M Tolomeo, A Nisco, M Barile - Flavins and Flavoproteins: Methods and …, 2021 - Springer
The aim of this short review chapter is to provide a brief summary of the relevance of
riboflavin (Rf or vitamin B2) and its derived cofactors flavin mononucleotide (FMN) and flavin …

AtDREB2G is involved in the regulation of riboflavin biosynthesis in response to low-temperature stress and abscisic acid treatment in Arabidopsis thaliana

J Namba, M Harada, R Shibata, Y Toda, T Maruta… - Plant Science, 2024 - Elsevier
Riboflavin (RF) serves as a precursor to flavin mononucleotide and flavin adenine
dinucleotide, which are crucial cofactors in various metabolic processes. Strict regulation of …

The hidden side of the human FAD synthase 2

P Leone, M Galluccio, C Brizio, A Barbiroli… - International Journal of …, 2019 - Elsevier
FAD synthase, the last enzyme of the pathway converting riboflavin to FAD, exists in humans
in different isoforms, with isoforms 1, 2 and 6 being characterized at the functional and …

Mechanism of enhanced salt tolerance in Saccharomyces cerevisiae by CRZ1 overexpression

F Zuo, Y Wu, Y Sun, C **e, Y Tang - Scientific Reports, 2024 - nature.com
Achieving high-gravity fermentation in the industrial production of fuel ethanol, and
enhancing the fermentation efficiency of high-salt raw materials, such as waste molasses …

Modulation of the subcellular levels of redox cofactors by Nudix hydrolases in chloroplasts

T Ogawa, K Yoshimura - Environmental and Experimental Botany, 2019 - Elsevier
Chloroplasts are organelles that generate reactive oxygen species (ROS) through redox
reactions during photosynthesis. It is now widely accepted that the redox state of the …

AtDREB2G is a novel regulator of riboflavin biosynthesis under low-temperature stress and abscisic acid treatment in Arabidopsis thaliana

J Namba, M Harada, Y Toda, T Maruta, T Ishikawa… - bioRxiv, 2023 - biorxiv.org
Riboflavin (RF) serves as a precursor to FMN and FAD, crucial cofactors in various
metabolic processes. Strict regulation of cellular flavin homeostasis is imperative, yet …

A higher plant FAD synthetase is fused to an inactivated FAD pyrophosphatase

JH Lynch, S Roje - Journal of Biological Chemistry, 2022 - jbc.org
The riboflavin derivatives FMN and flavin adenine dinucleotide (FAD) are critical cofactors
for wide-ranging biological processes across all kingdoms of life. Although it is well …

Funktionelle Charakterisierung der SUMOylierung des Nukleoporins Nup2 in Saccharomyces cerevisiae

HT Folz - 2020 - publikationen.sulb.uni-saarland.de
Nup2 ist ein Nukleoporin der Hefe, welches sich zusammen mit Nup60 und Nup1 an der
Kernseite des Kernporenkomplexes befindet. Im Rahmen dieser Arbeit wurde vorwiegend …