Type 2 immunity in the skin and lungs

CA Akdis, PD Arkwright, MC Brüggen, W Busse… - Allergy, 2020 - Wiley Online Library
There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

Allergen immunotherapy in children user's guide

M Alvaro‐Lozano, CA Akdis, M Akdis… - Pediatric allergy and …, 2020 - Wiley Online Library
Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …

[HTML][HTML] Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

K Golebski, JA Layhadi, U Sahiner, EH Steveling-Klein… - Immunity, 2021 - cell.com
The role of innate immune cells in allergen immunotherapy that confers immune tolerance to
the sensitizing allergen is unclear. Here, we report a role of interleukin-10-producing type 2 …

Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics, and perspectives—a report of the European Academy of Allergy and Clinical Immunology …

M Sokolowska, ZM Lukasik, I Agache, CA Akdis… - Allergy, 2020 - Wiley Online Library
With the worldwide spread of the novel severe acute respiratory syndrome coronavirus‐2
(SARS‐CoV‐2) resulting in declaration of a pandemic by the World Health Organization …

Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation

H Hong, S Liao, F Chen, Q Yang, DY Wang - Allergy, 2020 - Wiley Online Library
Under the concept of" united airway diseases," the airway is a single organ wherein upper
and lower airway diseases are commonly comorbid. The upper and lower airways are lined …

Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases

I Agache, CA Akdis - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
A rapidly develo** paradigm for modern health care is a proactive and individualized
response to patients' symptoms, combining precision diagnosis and personalized treatment …

Mechanisms of allergen-specific immunotherapy and allergen tolerance

UC Kucuksezer, C Ozdemir, L Cevhertas… - Allergology …, 2020 - jstage.jst.go.jp
abstract Allergen-specific immunotherapy (AIT) is the mainstay treatment for the cure of
allergic disorders, with depicted efficacy and safety by several trials and meta-analysis. AIT …

Laundry detergents and surfactants‐induced eosinophilic airway inflammation by increasing IL‐33 expression and activating ILC2s

K Saito, K Orimo, T Kubo, M Tamari, A Yamada… - Allergy, 2023 - Wiley Online Library
Introduction Epidemiological studies demonstrated that cleaning work and frequent use of
cleaning products are risk factors for asthma. Laundry detergents have been reported to …

Toward clinically applicable biomarkers for asthma: an EAACI position paper

Z Diamant, S Vijverberg, K Alving, A Bakirtas… - Allergy, 2019 - Wiley Online Library
Inflammation, structural, and functional abnormalities within the airways are key features of
asthma. Although these processes are well documented, their expression varies across the …

Handling of allergen immunotherapy in the COVID‐19 pandemic: an ARIA‐EAACI statement

L Klimek, M Jutel, C Akdis, J Bousquet, M Akdis… - Allergy, 2020 - Wiley Online Library
The current COVID-19 pandemic influences many areas of social life, medical treatments
and the way allergy diagnosis and treatment is performed. Allergen-specific immunotherapy …