The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …

In the late 1990s, mutations in the synaptic protein α-synuclein (α-syn) were identified in
families with hereditary Parkinson's disease (PD). Rapidly, α-syn became the target of …

Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

Toxicity of aggregation-prone proteins is thought to play an important role in aging and age-
related neurological diseases like Parkinson and Alzheimer's diseases. Here, we identify …

Polypharmacology-based strategies using drug combinations with different mechanisms of
action are gaining increasing attention as a novel methodology to discover potentially …

In 1997 a mutation in the a-synuclein (SNCA) gene was associated with familial autosomal
dominant Parkinson's disease (PD). Since then, several loci (PARK1‐15) and genes have …

Neurodegenerative diseases which include Alzheimer's disease (AD), Parkinson's disease
(PD), amyotrophic lateral sclerosis (ALS), Huntington disease (HD), and others are …

Neuronal function and differentiation are tightly regulated by both genome and epigenome.
Based on the environmental information the epigenetic changes occur. Neurodegeneration …

Parkinson's disease (PD) is a highly complex neurodegenerative disorder with a
multifactorial origin. Although several cellular mechanisms and genes have been implicated …

Neurodegenerative diseases represent an increasing burden in our aging society, yet the
underlying metabolic factors influencing onset and progression remain poorly defined. The …