Ecology, evolution and spillover of coronaviruses from bats

M Ruiz-Aravena, C McKee, A Gamble, T Lunn… - Nature Reviews …, 2022 - nature.com
In the past two decades, three coronaviruses with ancestral origins in bats have emerged
and caused widespread outbreaks in humans, including severe acute respiratory syndrome …

COVID-19: epidemiology, evolution, and cross-disciplinary perspectives

J Sun, WT He, L Wang, A Lai, X Ji, X Zhai, G Li… - Trends in molecular …, 2020 - cell.com
The recent outbreak of COVID-19 in Wuhan turned into a public health emergency of
international concern. With no antiviral drugs nor vaccines, and the presence of carriers …

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

YJ Hou, S Chiba, P Halfmann, C Ehre, M Kuroda… - Science, 2020 - science.org
The spike aspartic acid–614 to glycine (D614G) substitution is prevalent in global severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral …

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

M Letko, A Marzi, V Munster - Nature microbiology, 2020 - nature.com
Over the past 20 years, several coronaviruses have crossed the species barrier into
humans, causing outbreaks of severe, and often fatal, respiratory illness. Since SARS-CoV …

Bat-borne virus diversity, spillover and emergence

M Letko, SN Seifert, KJ Olival, RK Plowright… - Nature Reviews …, 2020 - nature.com
Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …

SARS-CoV-2 jum** the species barrier: Zoonotic lessons from SARS, MERS and recent advances to combat this pandemic virus

K Dhama, SK Patel, K Sharun, M Pathak… - Travel medicine and …, 2020 - Elsevier
Abstract Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2 (Severe Acute
Respiratory Syndrome-Coronavirus-2) of the family Coronaviridae, appeared in China in …

Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: A case study of bats

KJ Olival, PM Cryan, BR Amman, RS Baric… - PLoS …, 2020 - journals.plos.org
The COVID-19 pandemic highlights the substantial public health, economic, and societal
consequences of virus spillover from a wildlife reservoir. Widespread human transmission of …

Potential factors influencing repeated SARS outbreaks in China

Z Sun, K Thilakavathy, SS Kumar, G He… - International journal of …, 2020 - mdpi.com
Within last 17 years two widespread epidemics of severe acute respiratory syndrome
(SARS) occurred in China, which were caused by related coronaviruses (CoVs): SARS-CoV …

COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 (DPP4) in disease severity?

MF Bassendine, SH Bridge, GW McCaughan… - Journal of …, 2020 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic is caused by a novel
betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), similar …

Antitarget, anti-SARS-CoV-2 leads, drugs, and the drug discovery–genetics alliance perspective

C Pozzi, A Vanet, V Francesconi… - Journal of Medicinal …, 2023 - ACS Publications
The most advanced antiviral molecules addressing major SARS-CoV-2 targets (Main
protease, Spike protein, and RNA polymerase), compared with proteins of other human …