Liver fluke vaccines in ruminants: strategies, progress and future opportunities

H Toet, DM Piedrafita, TW Spithill - International journal for parasitology, 2014 - Elsevier
The development of a vaccine for Fasciola spp. in livestock is a challenge and would be
advanced by harnessing our knowledge of acquired immune mechanisms expressed by …

Update on trematode infections in sheep

FA Rojo-Vázquez, A Meana, F Valcárcel… - Veterinary …, 2012 - Elsevier
Trematode parasites live in the liver, fore stomachs or blood vessels of a wide range of
animals and humans. Most of them have a special economic and veterinary significance …

[HTML][HTML] Fasciola hepatica vaccine: we may not be there yet but we're on the right road

V Molina-Hernández, G Mulcahy, J Pérez… - Veterinary …, 2015 - Elsevier
Major advances have been made in identifying potential vaccine molecules for the control of
fasciolosis in livestock but we have yet to reach the level of efficacy required for …

Controversial aspects of the life cycle of Fasciola hepatica

M Moazeni, A Ahmadi - Experimental parasitology, 2016 - Elsevier
Fasciola hepatica is a well-known helminth parasite, with significant economic and public
health importance all over the world. It has been known since more than 630 years ago and …

Development of fish parasite vaccines in the OMICs era: Progress and opportunities

S Shivam, M El-Matbouli, G Kumar - Vaccines, 2021 - mdpi.com
Globally, parasites are increasingly being recognized as catastrophic agents in both
aquaculture sector and in the wild aquatic habitats leading to an estimated annual loss …

The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

K Cwiklinski, S Donnelly, O Drysdale, H Jewhurst… - Advances in …, 2019 - Elsevier
Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of
livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human …

Insights into Fasciola hepatica juveniles: crossing the fasciolosis rubicon

J González-Miguel, D Becerro-Recio… - Trends in …, 2021 - cell.com
Unraveling the molecular interactions governing the first contact between parasite and host
tissues is of paramount importance to the development of effective control strategies against …

Improving animal and human health through understanding liver fluke immunology

D Piedrafita, TW Spithill, RE Smith… - Parasite …, 2010 - Wiley Online Library
Sheep, goats and cattle represent the most numerous and economically important
agricultural species worldwide used as sources for milk, fibre and red meat. In addition, in …

Elucidating the transcriptome of Fasciola hepatica—a key to fundamental and biotechnological discoveries for a neglected parasite

ND Young, RS Hall, AR Jex, C Cantacessi… - Biotechnology …, 2010 - Elsevier
Liver flukes of animals are parasitic flatworms (Platyhelminthes: Digenea) of major
socioeconomic importance in many countries. Key representatives, such as Fasciola …

Efficacy of a multivalent vaccine against Fasciola hepatica infection in sheep

R Zafra, L Buffoni, R Pérez-Caballero… - Veterinary …, 2021 - Springer
In this work we report the protection found in a vaccination trial performed in sheep with two
different vaccines composed each one by a cocktail of antigens (rCL1, rPrx, rHDM and rLAP) …