The superfamily of proteins containing C‐type lectin‐like domains (CTLDs) is a large group
of extracellular Metazoan proteins with diverse functions. The CTLD structure has a …

Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

According to present concepts, innate immunity is regulated by receptors that determine
danger levels by responding to molecules that are associated with infection or cellular …

The localization of γδ T cells within epithelia suggests that these cells may contribute to the
down-regulation of epithelial malignancies. We report that mice lacking γδ cells are highly …

Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …

There has been marked progress in our understanding of the role of natural killer (NK) cells
in immune responses, mainly due to the identification of NK-cell receptors and their ligands …

The major histocompatibility complex (MHC) class I homolog, MICA, is a stress-inducible
ligand for NKG2D, a C-type lectin–like activating immunoreceptor. The crystal structure of …

In contrast to T cell receptors, signal transducing cell surface membrane molecules involved
in the regulation of responses by cells of the innate immune system employ structures that …

The recognition of human leukocyte antigen (HLA)-E by the heterodimeric CD94-NKG2
natural killer (NK) receptor family is a central innate mechanism by which NK cells monitor …

The activating NKG2D receptor plays a critical role in innate and adaptive immune
responses by natural killer cells and subpopulations of T cells. The human receptor …