Prevalence of statin intolerance: a meta-analysis
Aims Statin intolerance (SI) represents a significant public health problem for which precise
estimates of prevalence are needed. Statin intolerance remains an important clinical …
estimates of prevalence are needed. Statin intolerance remains an important clinical …
Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis
MG Silverman, BA Ference, K Im, SD Wiviott… - Jama, 2016 - jamanetwork.com
Importance The comparative clinical benefit of nonstatin therapies that reduce low-density
lipoprotein cholesterol (LDL-C) remains uncertain. Objective To evaluate the association …
lipoprotein cholesterol (LDL-C) remains uncertain. Objective To evaluate the association …
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology …
The Blood Cholesterol Expert Panel (Expert Panel) was originally convened as the Expert
Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult …
Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult …
Statin toxicity: mechanistic insights and clinical implications
NC Ward, GF Watts, RH Eckel - Circulation research, 2019 - Am Heart Assoc
There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …
Effects of extended-release niacin with laropiprant in high-risk patients
HPS2-Thrive Collaborative Group - New England Journal of …, 2014 - Mass Medical Soc
Background Patients with evidence of vascular disease are at increased risk for subsequent
vascular events despite effective use of statins to lower the low-density lipoprotein (LDL) …
vascular events despite effective use of statins to lower the low-density lipoprotein (LDL) …
Statin safety and associated adverse events: a scientific statement from the American Heart Association
CB Newman, D Preiss, JA Tobert… - … , and vascular biology, 2019 - Am Heart Assoc
One in 4 Americans> 40 years of age takes a statin to reduce the risk of myocardial
infarction, ischemic stroke, and other complications of atherosclerotic disease. The most …
infarction, ischemic stroke, and other complications of atherosclerotic disease. The most …
[HTML][HTML] Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Background Statin therapy is effective for the prevention of atherosclerotic cardiovascular
disease and is widely prescribed, but there are persisting concerns that statin therapy might …
disease and is widely prescribed, but there are persisting concerns that statin therapy might …
Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis
Context A recent meta-analysis demonstrated that statin therapy is associated with excess
risk of develo** diabetes mellitus. Objective To investigate whether intensive-dose statin …
risk of develo** diabetes mellitus. Objective To investigate whether intensive-dose statin …
Interpretation of the evidence for the efficacy and safety of statin therapy
This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …
about statin therapy for the prevention of heart attacks and strokes. It explains how the …
Statin-associated side effects
Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are well
tolerated, but associated with various statin-associated symptoms (SAS), including statin …
tolerated, but associated with various statin-associated symptoms (SAS), including statin …