Polysaccharide‐based controlled release systems for therapeutics delivery and tissue engineering: from bench to bedside

T Miao, J Wang, Y Zeng, G Liu, X Chen - Advanced science, 2018 - Wiley Online Library
Polysaccharides or polymeric carbohydrate molecules are long chains of monosaccharides
that are linked by glycosidic bonds. The naturally based structural materials are widely …

Polysaccharide-based nanoparticles for theranostic nanomedicine

M Swierczewska, HS Han, K Kim, JH Park… - Advanced drug delivery …, 2016 - Elsevier
Polysaccharides are natural biological molecules that have numerous advantages for
theranostics, the integrated approach of therapeutics and diagnostics. Their derivable …

Metabolic reconstruction for metagenomic data and its application to the human microbiome

S Abubucker, N Segata, J Goll… - PLoS computational …, 2012 - journals.plos.org
Microbial communities carry out the majority of the biochemical activity on the planet, and
they play integral roles in processes including metabolism and immune homeostasis in the …

Roles of proteoglycans and glycosaminoglycans in cancer development and progression

J Wei, M Hu, K Huang, S Lin, H Du - International journal of molecular …, 2020 - mdpi.com
The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of
ECM remodeling can lead to tumorigenesis and cancer development by providing favorable …

The structure of glycosaminoglycans and their interactions with proteins

NS Gandhi, RL Mancera - Chemical biology & drug design, 2008 - Wiley Online Library
Glycosaminoglycans (GAGs) are important complex carbohydrates that participate in many
biological processes through the regulation of their various protein partners. Biochemical …

B cell and B cell-related pathways for novel cancer treatments

R Tokunaga, M Naseem, JH Lo, F Battaglin… - Cancer treatment …, 2019 - Elsevier
B cells are recognized as the main effector cells of humoral immunity which suppress tumor
progression by secreting immunoglobulins, promoting T cell response, and killing cancer …

Medical application of glycosaminoglycans: a review

A Köwitsch, G Zhou, T Groth - Journal of tissue engineering …, 2018 - Wiley Online Library
The characteristic molecular composition of the different glycosaminoglycans (GAGs) is
related to their role as structural components and regulators of a multitude of functions of …

Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer

N Hassan, B Greve, NA Espinoza-Sánchez, M Götte - Cellular Signalling, 2021 - Elsevier
Proteoglycans (PGs) represent a large proportion of the components that constitute the
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …

Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis

H Zhou, M Wang, Y Zhang, Q Su, Z **e… - Cancer …, 2022 - Wiley Online Library
Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

Breast cancer stem cells, EMT and therapeutic targets

S Kotiyal, S Bhattacharya - Biochemical and biophysical research …, 2014 - Elsevier
A small heterogeneous population of breast cancer cells acts as seeds to induce new tumor
growth. These seeds or breast cancer stem cells (BCSCs) exhibit great phenotypical …