By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR)
improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings …

Microsatellites, or tandem simple sequence repeats (SSR), are abundant across genomes
and show high levels of polymorphism. SSR genetic and evolutionary mechanisms remain …

Mutations are rare events, occurring spontaneously at a frequency of 1 per 109-1010 base
pairs per cell division. 1, 2 Nucleotide misincorporation during DNA synthesis yields …

Disease-causing repeat instability is an important and unique form of mutation that is linked
to more than 40 neurological, neurodegenerative and neuromuscular disorders. DNA repeat …

DNA mismatch repair (MMR) is a highly conserved genome stabilizing pathway that corrects
DNA replication errors, limits chromosomal rearrangements, and mediates the cellular …

Microsatellites are a ubiquitous class of simple repetitive DNA sequences, which are
widespread in both eukaryotic and prokaryotic genomes. The use of microsatellites as …

Currently, genetic ty** of microorganisms is widely used in several major fields of
microbiological research. Taxonomy, research aimed at elucidation of evolutionary …

Abstract (CGG) n (CCG) n and (CTG) n (CAG) n repeats of varying length were cloned into a
bacterial plasmid, and the progression of the replication fork through these repeats was …

Triplet repeat expansion diseases (TREDs) are characterized by the coincidence of disease
manifestation with amplification of d (CAG· CTG), d (CGG· CCG) or d (GAA· TTC) repeats …

Friedreich ataxia (FRDA) is associated with the expansion of a GAA· TTC triplet repeat in the
first intron of the frataxin gene, resulting in reduced levels of frataxin mRNA and protein. To …