Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Dissecting the in vitro fate of plant-derived bioactive encapsulated nanoparticles in lung diseases

AB Saeid, VK Patel, S Mehndiratta, R Rajput… - Food Bioscience, 2023 - Elsevier
Lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung
cancer are prevalent worldwide, with high mortality rates. There are many pathways …

18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration

KR Paudel, MSB Mohamad, G De Rubis… - Journal of Drug Delivery …, 2024 - Elsevier
Conventional treatment methods to treat lung cancer include radiation therapy,
chemotherapy, and immunotherapy. However, they cause severe adverse effects and …

In vitro anti-cancer activity of a polyherbal preparation, VEDICINALS® 9, against A549 human lung adenocarcinoma cells

KR Paudel, R Rajput, G De Rubis, VSRR Allam… - … -Research and Practice, 2023 - Elsevier
Purpose Non-small cell lung cancer (NSCLC) is among the leading causes of morbidity and
mortality worldwide. Despite the availability of several treatment options, the five-year …

Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro

B Manandhar, KR Paudel, DD Clarence… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer is the second most prevalent type of cancer and is responsible for the highest
number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up …

Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells

G De Rubis, KR Paudel, G Liu, V Agarwal… - Toxicology in Vitro, 2023 - Elsevier
Airway remodelling occurs in chronic respiratory diseases (CRDs) such as asthma and
chronic obstructive pulmonary disease (COPD). It is characterized by aberrant activation of …

Agarwood oil nanoemulsion counteracts LPS-induced inflammation and oxidative stress in RAW264. 7 mouse macrophages

R Malik, KR Paudel, B Manandhar, G De Rubis… - … -Research and Practice, 2023 - Elsevier
Purpose Oxidative stress and inflammation are key pathophysiological features of chronic
respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD) …

[HTML][HTML] Therapeutic potential of 18-β-glycyrrhetinic acid-loaded poly (lactic-co-glycolic acid) nanoparticles on cigarette smoke-induced in-vitro model of COPD

T El Sherkawi, AB Saeid, S Yeung… - … -Research and Practice, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) is strongly linked to cigarette smoke, which
contains toxins that induce oxidative stress and airway inflammation, ultimately leading to …

Epithelial–mesenchymal transition in chemoradiation‐induced lung damage: Mechanisms and potential treatment approaches

MJ Saadh, P Sharma, IH Naser… - … of Biochemical and …, 2024 - Wiley Online Library
Pulmonary injury is one of the key restricting factors for the therapy of malignancies with
chemotherapy or following radiotherapy for chest cancers. The lung is a sensitive organ to …