Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

Mitochondrial dysfunction has been described as an early pathological mechanism
delineating the selective neurodegeneration that occurs in Huntington's disease (HD), a …

Neurodegenerative diseases are featured by progressive dysfunction and death of cells in
selected areas in the nervous system, determining clinical presentation. Neuronal loss is …

Traumatic brain injury (TBI) occurs when an outside force impacts the brain. The main
problem associated with TBI is neuronal cell death of the brain, and the outcome of TBI …

Abstract Background Huntington's Disease (HD) is a progressive neurodegenerative
disorder with a single causal mutation in the Huntingtin (HTT) gene. MicroRNAs (miRNAs) …

The history of polyglutamine diseases dates back approximately 20 years to the discovery of
a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of …

Kaempferol, a natural flavonoid present in fruits, vegetables, and teas, provides beneficial
effects for human health. In this study, we investigated the protective effects of kaempferol on …

Repeat expansion diseases are a group of neuromuscular and neurodegenerative
disorders characterized by expansions of several successive repeated DNA sequences …

Huntington's disease (HD), a neurodegenerative disorder caused by mutant huntingtin, is
characterized by a catabolic phenotype. To determine the mechanisms underlying muscle …

Transient increase in cytosolic (Cac2+) and mitochondrial Ca2+ (Ca m2+) are essential
elements in the control of many physiological processes. However, sustained increases in …