A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice
X Liu, Z Li, X Li, W Wu, H Jiang, Y Zheng, J Zhou… - Nature …, 2024 - nature.com
Antibody-dependent enhancement (ADE) is a potential concern for the development of Zika
virus (ZIKV) vaccines. Cross-reactive but poorly neutralizing antibodies, usually targeting …
virus (ZIKV) vaccines. Cross-reactive but poorly neutralizing antibodies, usually targeting …
In vitro transcribed RNA-based platform vaccines: past, present, and future
AD Perenkov, AD Sergeeva, MV Vedunova, DV Krysko - Vaccines, 2023 - mdpi.com
mRNA was discovered in 1961, but it was not used as a vaccine until after three decades.
Recently, the development of mRNA vaccine technology gained great impetus from the …
Recently, the development of mRNA vaccine technology gained great impetus from the …
Innovative translational platforms for rapid develo** clinical vaccines against COVID‐19 and other infectious disease
N Wang, T Wang - Biotechnology Journal, 2024 - Wiley Online Library
A vaccine is a biological preparation that contains the antigen capable of stimulating the
immune system to form the defense against pathogens. Vaccine development often …
immune system to form the defense against pathogens. Vaccine development often …
Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA
We developed phosphorylation reagents with a nitrobenzyl hydrophobic tag and used them
for 5′-phosphorylation of chemically or transcriptionally synthesized RNA. The capability of …
for 5′-phosphorylation of chemically or transcriptionally synthesized RNA. The capability of …
[PDF][PDF] Recent Findings on Therapeutic Cancer Vaccines: An Updated Review
S Sheikhlary - 2024 - videleaf.com
Cancer remains one of the global leading causes of death and various vaccines have been
developed over the years against it, including cell-based, nucleic acid-based, and viral …
developed over the years against it, including cell-based, nucleic acid-based, and viral …
Engineering an Escherichia coli based in vivo mRNA manufacturing platform
Synthetic mRNA is currently produced in standardized in vitro transcription systems.
However, this one‐size‐fits‐all approach has associated drawbacks in supply chain …
However, this one‐size‐fits‐all approach has associated drawbacks in supply chain …
Systematic screen of RNA binding proteins that enhance circular RNA translation
Q Lu, S Wang, Y Ye, Y Yang, Z Wang - bioRxiv, 2024 - biorxiv.org
Translatable circular RNAs (circRNAs) have emerged as a promising alternative to linear
mRNA as new therapeutics due to its improved stability. The translation of circRNAs is …
mRNA as new therapeutics due to its improved stability. The translation of circRNAs is …