Modulation of innate and adaptive immunity by cytomegaloviruses
The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …
against viruses. To counter this, some viruses have evolved sophisticated strategies to …
Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2
Cancer immunotherapy aims to initiate or amplify immune responses that eliminate cancer
cells and create immune memory to prevent relapse. Immune checkpoint inhibitors (ICIs) …
cells and create immune memory to prevent relapse. Immune checkpoint inhibitors (ICIs) …
Emergence of the CD226 axis in cancer immunotherapy
M Conner, KW Hance, S Yadavilli, J Smothers… - Frontiers in …, 2022 - frontiersin.org
In recent years, a set of immune receptors that interact with members of the nectin/nectin-like
(necl) family has garnered significant attention as possible points of manipulation in cancer …
(necl) family has garnered significant attention as possible points of manipulation in cancer …
DNAM-1 versus TIGIT: competitive roles in tumor immunity and inflammatory responses
A Shibuya, K Shibuya - International immunology, 2021 - academic.oup.com
The co-stimulatory and co-inhibitory immunoreceptors, DNAX accessory molecule-1 (DNAM-
1) and T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based …
1) and T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based …
CD155 in tumor progression and targeted therapy
M Zhan, Z Zhang, X Zhao, Y Zhang, T Liu, L Lu, XY Li - Cancer Letters, 2022 - Elsevier
CD155, also known as the poliovirus receptor (PVR), has received considerable attention in
recent years because of its intrinsic and extrinsic roles in tumor progression. Although barely …
recent years because of its intrinsic and extrinsic roles in tumor progression. Although barely …
Cancer immunotherapy and the nectin family
It is increasingly clear that the nectin family and its immunoreceptors shape the immune
response to cancer through several pathways. Yet, even as antibodies against TIGIT, CD96 …
response to cancer through several pathways. Yet, even as antibodies against TIGIT, CD96 …
Nectin family ligands trigger immune effector functions in health and autoimmunity
D Hermans, L van Beers, B Broux - Biology, 2023 - mdpi.com
Simple Summary Immune-cell activation is triggered upon antigen or target recognition. This
is modulated by co-stimulatory or co-inhibitory signals provided by the cellular environment …
is modulated by co-stimulatory or co-inhibitory signals provided by the cellular environment …
MD Simulation Reveals Regulation of Mechanical Force and Extracellular Domain 2 on Binding of DNAM-1 to CD155
L Fang, Y Zhao, P Guo, Y Fang, J Wu - Molecules, 2023 - mdpi.com
Two extracellular domains of the adhesive receptor DNAM-1 are involved in various cellular
biological processes through binding to ligand CD155, usually under a mechano …
biological processes through binding to ligand CD155, usually under a mechano …
The CC′ loop of IgV domains of the immune checkpoint receptors, plays a key role in receptor: ligand affinity modulation
Antibodies targeting negative regulators of immune checkpoints have shown unprecedented
and durable response against variety of malignancies. While the concept of blocking the …
and durable response against variety of malignancies. While the concept of blocking the …
Essential role of CD155 glycosylation in functional binding to DNAM-1 on natural killer cells
S Tahara, G Okumura, T Matsuo… - International …, 2024 - academic.oup.com
The cluster of differentiation 155 (CD155) is highly expressed on tumor cells and augments
or inhibits the cytotoxic activities of natural killer (NK) cells and T cells through its receptor …
or inhibits the cytotoxic activities of natural killer (NK) cells and T cells through its receptor …