Primary immune thrombocytopenia: novel insights into pathophysiology and disease management

A Singh, G Uzun, T Bakchoul - Journal of Clinical Medicine, 2021 - mdpi.com
Immune thrombocytopenia (ITP) is an autoimmune disorder defined by a significantly
reduced number of platelets in blood circulation. Due to low levels of platelets, ITP is …

The immune thrombocytopenia paradox: Should we be concerned about thrombosis in ITP?

A Saldanha, MP Colella, PR Villaça, J Thachil… - Thrombosis research, 2024 - Elsevier
Despite the predisposition to bleeding, patients with immune thrombocytopenia (ITP) may
also have an increased risk of arterial and venous thrombosis, which can contribute to …

Platelets in ITP: victims in charge of their own fate?

VS Nelson, ATC Jolink, SN Amini, JJ Zwaginga… - Cells, 2021 - mdpi.com
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The
pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved …

Pathophysiology of autoimmune thrombocytopenia: current insight with a focus on thrombopoiesis

I Marini, T Bakchoul - Hämostaseologie, 2019 - thieme-connect.com
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a significant
reduction in the number of circulating platelets which is frequently associated with bleeding …

Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis

S Yang, L Wang, Y Wu, A Wu, F Huang… - Frontiers in …, 2023 - frontiersin.org
Platelets, generated from precursor megakaryocytes (MKs), are central mediators of
hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated …

[HTML][HTML] Desialylation and Apoptosis in Immune Thrombocytopenia: Implications for Pathogenesis and Treatment

SS Zheng, JS Perdomo - Current Issues in Molecular Biology, 2024 - mdpi.com
Immune thrombocytopenia (ITP) is an autoimmune disease in which platelet autoantibodies
play a significant role in its pathogenesis. Regulatory T cell dysfunction and T cell-mediated …

The extensive regulation of microRNA in immune thrombocytopenia

Y Zhao, S Cui, Y Wang, R Xu - Clinical and Applied …, 2022 - journals.sagepub.com
MicroRNA (miRNA) is a small, single-stranded, non-coding RNA molecule that plays a
variety of key roles in different biological processes through post-transcriptional regulation of …

Insights on chronic immune thrombocytopenia pathogenesis: a bench to bedside update

JC Jaime-Pérez, EM Ramos-Dávila… - Blood Reviews, 2021 - Elsevier
Immune thrombocytopenia (ITP) is a heterogeneous disease with an unpredictable course.
Chronicity can develop in up to two-thirds of adults and 20–25% of children, representing a …

Significant reductions in apoptosis-related proteins (HSPA6, HSPA8, ITGB3, YWHAH, and PRDX6) are involved in immune thrombocytopenia

S Liu, D Yuan, RJ Sun, J Zhu, N Shan - Journal of Thrombosis and …, 2021 - Springer
To investigate differences in the expression of plasma proteins in immune thrombocytopenia
(ITP) and normal control groups, bone marrow samples were collected from 20 active ITP …

The intestinal flora: The key to unraveling heterogeneity in immune thrombocytopenia?

JM Schoenaker, VS Nelson, JGE Henderickx… - Blood Reviews, 2024 - Elsevier
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by
enhanced platelet destruction and impaired platelet production, due to a loss of immune …